ArticleSocial psychiatry and psychiatric epidemiology2021
Prevalence and clinical correlates of substance use disorders in South African Xhosa patients with schizophrenia.
Article in Social psychiatry and psychiatric epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Alcohol use disorder and associated factors among individuals with severe mental illnesses in Africa: a systematic review and meta-analysis.Social psychiatry and psychiatric epidemiology · 2026Pooled it
- ADHD and schizophrenia: Mere prodromal variant or homogeneous subgroup?Schizophrenia research. Cognition · 2025Article
- Management of schizophrenia and comorbid substance use disorders: expert review and guidance.Annals of general psychiatry · 2024Review
- Disability benefits protect against lost income for South Africans living with Schizophrenia.Social psychiatry and psychiatric epidemiology · 2024Article
- Integrating Electronic Health Records and Polygenic Risk to Identify Genetically Unrelated Comorbidities of Schizophrenia That May Be Modifiable.Biological psychiatry global open science · 2024Article
- Patterns of Psychiatric Illness in a Tertiary Care Centre of Arunachal Pradesh: An Observational Study.Maedica · 2022Article
- Prevalence of cannabis use in people with psychosis in KwaZulu-Natal, South Africa.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2022Article
- Interlinking alcohol intake, mental stress, psychotic experiences and job performance of higher institutions' graduates: A structural equation modelling.Journal of education and health promotion · 2022Article
- Substance Use Disorder Among Patients with Primary Mental Illnesses in Southwestern Uganda.Journal of dual diagnosisArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTo determine the prevalence of substance use disorders (SUDs) in patients with schizophrenia in a sample from South Africa and compare the clinical and demographic correlates in those with and without co-occurring SUDs.
methodsPatients with schizophrenia were interviewed using the Xhosa version SCID-I for DSM-IV. We used logistic regression to determine the predictors of SUDs.
resultsIn the total sample of 1420 participants, SUDs occurred in 47.8%, with the most prevalent SUD being cannabis use disorders (39.6%), followed by alcohol (20.5%), methaqualone (6.2%), methamphetamine (4.8%) and other SUDs (cocaine, ecstasy, opioids, 0.6%). Polydrug use occurred in 40%, abuse occurred in 13.5%, and 39.6% had at least one substance dependence diagnosis. Significant predictors of any SUD were younger age (41-55 vs. 21-30: OR = 0.7, 95% CI = 0.5-0.9), male sex (OR = 8.6, 95% CI = 5.1-14.6), inpatient status (OR = 1.7, 95% CI = 1.3-2.1), post-traumatic stress symptoms (OR = 4.6, 95% CI = 1.6-13.3), legal (OR = 3.4, 95% CI = 2.0-5.5) and economic problems (OR = 1.4, 95% CI = 1.0-2.0). Methamphetamine use disorders occurred significantly less often in the Eastern compared to the Western Cape provinces. Inpatient status and higher levels of prior admissions were significantly associated with cannabis and methamphetamine use disorders. Post-traumatic stress symptoms were significantly associated with alcohol use disorders. Anxiety disorders were associated with other SUDs.
conclusionSUDs occurred in almost half of the sample. It is important for clinicians to identify the presence of SUDs as their presence is associated with characteristics, such as male sex, younger age, inpatient status, more prior hospitalisations, legal and economic problems, PTSD symptoms and anxiety.
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