SynthesisInvestigative ophthalmology & visual science2020
Clinical and Prodromal Ocular Symptoms in Coronavirus Disease: A Systematic Review and Meta-Analysis.
Synthesis in Investigative ophthalmology & visual science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 7 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Impact of coronavirus disease 2019 pandemic on the trends of care-seeking behavior for ocular diseases: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- TFOS lifestyle: Impact of societal challenges on the ocular surface.The ocular surface · 2023Pooled it
- Retinal microvascular impairment in COVID-19 patients: A meta-analysis.Immunity, inflammation and disease · 2022Pooled it
- Hearing Loss, Tinnitus, and Dizziness in COVID-19: A Systematic Review and Meta-Analysis.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2022Pooled it
- Pooled Prevalence Estimate of Ocular Manifestations in COVID-19 Patients: A Systematic Review and Meta-Analysis.Iranian journal of medical sciences · 2022Pooled it
- COVID 19 repercussions in ophthalmology: a narrative review.Sao Paulo medical journal = Revista paulista de medicinaPooled it
- Ocular manifestations in COVID-19 patients: A systematic review and meta-analysis.Travel medicine and infectious diseasePooled it
- External Ocular Manifestations among Patients Diagnosed with Coronavirus Disease 2019 in a Referral Center in the Philippines.Acta medica Philippina · 2026Article
- New-onset conjunctivitis 3.5 years post SARS-CoV-2 infection in an inner-city population in the Bronx.BMJ open ophthalmology · 2025Article
- Ocular neuroinflammatory response secondary to SARS-CoV-2 infection-a review.Frontiers in immunology · 2025Review
- Review
- Relationship between dry eye disease and myopia: A systematic review and meta-analysis.Heliyon · 2024Article
- Impact of the Coronavirus Disease 2019 Pandemic on Outpatient Visits for Diabetic Retinopathy in Japan: A Retrospective Cohort Study.Translational vision science & technology · 2024Article
- The impact of COVID-19 on hay fever treatment in Japan: A retrospective cohort study based on the Japanese claims database.Clinical and translational allergy · 2024Article
- Article
- Characteristics of ocular findings of patients with coronavirus disease 2019 in China.Frontiers in medicine · 2024Article
- Unilateral branch retinal artery occlusion in association with COVID-19: a case report.International journal of ophthalmology · 2024Article
- Article
- Dyslipidemia Exacerbates Meibomian Gland Dysfunction: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- P4 Medicine for Heterogeneity of Dry Eye: A Mobile Health-based Digital Cohort Study.Juntendo Iji zasshi = Juntendo medical journal · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This systematic review aimed to determine currently reported clinical and prodromal ocular symptoms in patients with coronavirus disease 2019 (COVID-19). Methods: An online article search was performed in PubMed and EMBASE. Altogether 15 studies (retrospective, prospective, or case studies) involving 1533 patients with COVID-19, reporting on ocular symptoms, and with outcome data available were identified. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting guidelines were followed. Study-specific estimates (incidence rates of ocular symptoms in patients with COVID-19) of cases were combined using one-group meta-analysis in a random-effects model. Results: Of all included studies, 11.2% (95% confidence interval, 5.5-16.9; 78/1526 cases) reported ocular symptoms. The most common ocular finding was conjunctivitis. Prodromal ocular symptoms occurred in 12.5% (13/104 cases) of patients with COVID-19. Positive real-time polymerase chain reaction results were obtained for 16.7% (10/60 cases) of conjunctival samples and 0% (0/17 cases) of tear samples. Twelve ocular conjunctival swab samples tested positive for SARS-CoV-2. Ten cases were from subjects showing ocular symptoms (16.7%, 10/60 cases), and the remaining two cases were from subjects without ocular manifestation (1.8%, 2/113 cases). Limitations included the short study period, small sample size, findings were limited to the Asian population, only seven articles included ophthalmologic examination details, and there is currently no consensus on COVID-19 management. Conclusions: Ocular symptoms may occur in the presymptomatic phase as a prodromal symptom (12.5%, 13/104 cases), suggesting the possibility of viral transmission from the conjunctiva.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.