ArticleGenome biology and evolution2020
Comparative Genomics Underlines Multiple Roles of Profftella, an Obligate Symbiont of Psyllids: Providing Toxins, Vitamins, and Carotenoids.
Article in Genome biology and evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 62 citations in OpenAlex.
- Genome-Wide Association Study Reveals Insect Genetics and Microbial Symbiont Effects on Susceptibility of Diaphorina citri to the Citrus Greening Pathogen, Candidatus Liberibacter Asiaticus.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Evolutionary dynamics of obligate endosymbiosis in the psyllid genus Cacopsylla.Communications biology · 2025Article
- The Endosymbiont Consortia of Two Cixiidae Planthoppers Reveal an Ancient Symbiosis With 'Candidatus Mirabilia Symbiotica'.Environmental microbiology reports · 2025Article
- Enigmatic tubular ultrastructure in the bacterial defensive symbiont of the Asian citrus psyllid Diaphorina citri.Npj imaging · 2025Article
- Characterising the Associated Virome and Microbiota of Asian Citrus Psyllid (Pathogens (Basel, Switzerland) · 2025Article
- Complete genome of the mutualistic symbiont "Microbiology resource announcements · 2025Article
- A dual insect symbiont and plant pathogen improves insect host fitness under arginine limitation.mBio · 2025Article
- Rapid Loss of Nutritional Symbionts in an Endemic Hawaiian Herbivore Radiation Is Associated with Plant Galling Habit.Molecular biology and evolution · 2024Article
- A limited concentration range of diaphorin, a polyketide produced by a bacterial symbiont of the Asian citrus psyllid, promotes theMicrobiology spectrum · 2024Article
- Insect-microbe interactions and their influence on organisms and ecosystems.Ecology and evolution · 2024Review
- With a little help from my friends: the roles of microbial symbionts in insect populations and communities.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- PacBio Hi-Fi genome assembly of Sipha maydis, a model for the study of multipartite mutualism in insects.Scientific data · 2024Article
- Ultrastructure of the bacteriome and bacterial symbionts in the Asian citrus psyllid,Microbiology spectrum · 2024Article
- Highly Reduced Complementary Genomes of Dual Bacterial Symbionts in the Mulberry Psyllid Anomoneura mori.Microbes and environments · 2024Article
- Division of labor within psyllids: metagenomics reveals an ancient dual endosymbiosis with metabolic complementarity in the genusmSystems · 2023Article
- Unveiling metabolic integration in psyllids and their nutritional endosymbionts through comparative transcriptomics analysis.iScience · 2023Article
- Seasonal wild dance of dual endosymbionts in the pear psyllid Cacopsylla pyricola (Hemiptera: Psylloidea).Scientific reports · 2023Article
- Article
- 16S rRNA Gene Sequencing of Six Psyllid Species of the Family Carsidaridae Identified Various Bacteria Including Symbiopectobacterium.Microbes and environments · 2023Article
- Microbiome of pear psyllids: A tale about closely related species sharing their endosymbionts.Environmental microbiology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Asian citrus psyllid Diaphorina citri (Insecta: Hemiptera: Psylloidea), a serious pest of citrus species worldwide, harbors vertically transmitted intracellular mutualists, Candidatus Profftella armatura (Profftella_DC, Gammaproteobacteria: Burkholderiales) and Candidatus Carsonella ruddii (Carsonella_DC, Gammaproteobacteria: Oceanospirillales). Whereas Carsonella_DC is a typical nutritional symbiont, Profftella_DC is a unique defensive symbiont with organelle-like features, including intracellular localization within the host, perfect infection in host populations, vertical transmission over evolutionary time, and drastic genome reduction down to much less than 1 Mb. Large parts of the 460-kb genome of Profftella_DC are devoted to genes for synthesizing a polyketide toxin; diaphorin. To better understand the evolution of this unusual symbiont, the present study analyzed the genome of Profftella_Dco, a sister lineage to Profftella_DC, using Diaphorina cf. continua, a host psyllid congeneric with D. citri. The genome of coresiding Carsonella (Carsonella_Dco) was also analyzed. The analysis revealed nearly perfect synteny conservation in these genomes with their counterparts from D. citri. The substitution rate analysis further demonstrated genomic stability of Profftella which is comparable to that of Carsonella. Profftella_Dco and Profftella_DC shared all genes for the biosynthesis of diaphorin, hemolysin, riboflavin, biotin, and carotenoids, underlining multiple roles of Profftella, which may contribute to stabilizing symbiotic relationships with the host. However, acyl carrier proteins were extensively amplified in polyketide synthases DipP and DipT for diaphorin synthesis in Profftella_Dco. This level of acyl carrier protein augmentation, unprecedented in modular polyketide synthases of any known organism, is not thought to influence the polyketide structure but may improve the synthesis efficiency.
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