ArticlePLoS neglected tropical diseases2020
The role of an active surveillance strategy of targeting household and neighborhood contacts related to leprosy cases released from treatment in a low-endemic area of China.
Article in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Systematic Review of Survival Analysis in Leprosy Studies-Including the Following Outcomes: Relapse, Impairment of Nerve Function, Reactions and Physical Disability.International journal of environmental research and public health · 2022Pooled it
- Mycobacterium leprae transmission characteristics during the declining stages of leprosy incidence: A systematic review.PLoS neglected tropical diseases · 2021Pooled it
- Serum geoepidemiology of leprosy biomarkers in a city-wide COVID-19 survey in Brazil.BMC infectious diseases · 2026Article
- Elderly care needs and factors influencing negative emotions among first-generation only child parents in a Chinese city.World journal of psychiatry · 2025Article
- Identifying promising peptide targets for leprosy serological tests: From prediction to ELISA.Journal, genetic engineering & biotechnology · 2025Article
- Potentially disabling factors of newly diagnosed leprosy patients in southwest China: a retrospective observational study.BMC public health · 2025Observational
- Exploring Active Case Detection Approaches for Leprosy Diagnosis in Varied Endemic Settings: A Comprehensive Scoping Review.Life (Basel, Switzerland) · 2024Article
- Case detection delay in leprosy: Testing tool reliability and measurement consistency in Ethiopia, Mozambique, and Tanzania.PLoS neglected tropical diseases · 2024Article
- Training and Active Case Detection to Prevent Leprosy: Effect on Knowledge, Attitude and Skills of Health Workers on Early Diagnosis of Leprosy in a Leprosy Hotspot District in Ethiopia.Tropical medicine and infectious disease · 2024Article
- Reaching those at risk: Active case detection of leprosy and contact tracing at Kokosa, a hot spot district in Ethiopia.PloS one · 2023Article
- Epidemiological scenario of leprosy in marginalized communities of India: Focus on scheduled tribes.The Indian journal of medical research · 2022Review
- Risk factors for physical disability in patients with leprosy disease in Yunnan, China: Evidence from a retrospective observational study.PLoS neglected tropical diseases · 2021Observational
- Evidence for hidden leprosy in a high leprosy-endemic setting, Eastern Ethiopia: The application of active case-finding and contact screening.PLoS neglected tropical diseases · 2021Article
- A Literature Review: The History of Psychological Impact of Illness amongst People with Leprosy (PwL) in Countries across the Globe.Dermatology research and practice · 2021Review
- Serum IgA Antibodies Specific toFrontiers in medicine · 2021Article
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Authors and funding
20 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEarly diagnosis remains the primary goal for leprosy management programs. This study aims to determine whether active surveillance of patients with leprosy and their contact individuals increased identification of latent leprosy cases in the low-endemic areas.
methodsThis cross-sectional survey was carried out between October 2014 and August 2016 in 21 counties throughout Shandong Province. The survey was conducted among patients with leprosy released from treatment (RFT) and their contacts from both household and neighbors.
resultsA total of 2,210 RFT patients and 9,742 contacts comprising 7877 household contacts (HHCs), including 5,844 genetic related family members (GRFMs) and 2033 non-genetic related family members and 1,865 contacts living in neighboring houses (neighbor contacts, NCs), were recruited. Among identified individuals, one relapsed and 13 were newly diagnosed, giving a detection rate of 0.12%, corresponding to 120 times the passive case detection rate. Detection rates were similar for HHCs and NCs (0.114% vs. 0.214%, P = 0.287). Analysis of the family history of leprosy patients revealed clustering of newly diagnosed cases and association with residential coordinates of previously-diagnosed multibacillary leprosy cases.
conclusionActive case-finding programs are feasible and contributes to early case detection by tracking HHCs and NCs in low-endemic areas.
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