SynthesisPloS one2020
Impact of cardiovascular risk profile on COVID-19 outcome. A meta-analysis.
Synthesis in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 56 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 5 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- COVID-19-associated Brugada pattern electrocardiogram: Systematic review of case reports.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2023Pooled it
- Pre-existing health conditions and severe COVID-19 outcomes: an umbrella review approach and meta-analysis of global evidence.BMC medicine · 2021Pooled it
- Cardiovascular risk factors, cardiovascular disease, and COVID-19: an umbrella review of systematic reviews.European heart journal. Quality of care & clinical outcomes · 2021Pooled it
- ACC Health Policy Statement on Cardiovascular Disease Considerations for COVID-19 Vaccine Prioritization: A Report of the American College of Cardiology Solution Set Oversight Committee.Journal of the American College of Cardiology · 2021Guideline
- Cardiovascular risk factors and mortality in hospitalized patients with COVID-19: systematic review and meta-analysis of 45 studies and 18,300 patients.BMC cardiovascular disorders · 2021Pooled it
- Temporal Evolution of the Impact of CKD on COVID-19 Outcomes : A 5-Year Nationwide Analysis.Kidney360 · 2026Article
- Increase in cardiovascular deaths during the COVID-19 pandemic in Peru: a 5-year analysis of the national death system.Open heart · 2026Observational
- Predicting COVID-19 Mortality Risk Among Cardiovascular Disease Patients Using Artificial Intelligence Algorithms: A Retrospective Study on Clinical Data.Health science reports · 2026Article
- Explainable artificial intelligence for predicting cardiovascular events in hospitalised COVID-19 patients.BMC infectious diseases · 2025Article
- The Role of Comorbidities in COVID-19 Severity.Viruses · 2025Observational
- Sex and other predictors of mortality in long-term follow-up of patients with cardiovascular disease and COVID-19: a single-center retrospective study.Scientific reports · 2025Article
- Article
- Different clinical characteristics and outcomes of adult hospitalized SARS-CoV-2 pneumonia patients complicated by cardiovascular events during the first, delta and omicron waves of COVID-19.Frontiers in epidemiology · 2024Article
- Article
- Using cardiovascular risk indices to predict mortality in Covid-19 patients with acute respiratory distress syndrome: a cross sectional study.Scientific reports · 2023Article
- Cardiovascular Complications in Patients Hospitalized for COVID-19: A Cohort Study in Havana, Cuba.Cardiovascular revascularization medicine : including molecular interventions · 2023Article
- Epidemiological Features and Outcomes of COVID-19 in Patients With and Without Cardiovascular Disease.Archives of Iranian medicine · 2023Article
- Article
- Long-Term Impact of COVID-19 on Heart Rate Variability: A Systematic Review of Observational Studies.Healthcare (Basel, Switzerland) · 2023Review
- Acute Cardiovascular Events After COVID-19 in England in 2020: A Self-Controlled Case Series Study.Clinical epidemiology · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe ongoing pandemic of Novel Coronavirus Disease 2019 (COVID-19) infection has created a global emergency. Despite the infection causes a mild illness to most people, some patients are severely affected, demanding an urgent need to better understand how to risk-stratify infected subjects.
designThis is a meta-analysis of observational studies evaluating cardiovascular (CV) complications in hospitalized COVID-19 patients and the impact of cardiovascular risk factors (RF) or comorbidities on mortality.
methodsData sources: PubMed, Scopus, and ISI from 1 December 2019 through 11 June 2020; references of eligible studies; scientific session abstracts; cardiology web sites. We selected studies reporting clinical outcomes of hospitalized patients with COVID-19. The main outcome was death. Secondary outcomes were cardiovascular symptoms and cardiovascular events developed during the COVID-19-related hospitalization. Extracted data were recorded in excel worksheets and analysed using statistical software (MedCalc, OpenMetanalyst, R). We used the proportion with 95% CI as the summary measure. A Freeman-Tukey transformation was used to calculate the weighted summary proportion under the random-effects model. Heterogeneity was assessed by using the Cochran Q test and I2 values.
resultsAmong 77317 hospitalized patients from 21 studies, 12.86% had cardiovascular comorbidities or RF. Cardiovascular complications were registered in 14.09% of cases during hospitalization. At meta-regression analysis, pre-existing cardiovascular comorbidities or RF were significantly associated to cardiovascular complications in COVID-19 patients (p = 0.019). Pre-existing cardiovascular comorbidities or RF (p<0.001), older age (p<0.001), and the development of cardiovascular complications during the hospitalization (p = 0.038) had a significant interaction with death.
conclusionsCardiovascular complications are frequent among COVID-19 patients, and might contribute to adverse clinical events and mortality, together with pre-existing cardiovascular comorbidities and RF. Clinicians worldwide should be aware of this association, to identifying patients at higher risk.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.