ArticleNature communications2020
Genomic characterization of malignant progression in neoplastic pancreatic cysts.
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Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.
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73citing papers in PubMed, 2 pooled it
6.8field-weighted citation impact, top 2% of its field
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Who cites it
73 citing papers in PubMed, 2 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- Implications and risk of new versus persisting intraductal papillary mucinous neoplasms after pancreatic surgery: meta-analysis.BJS open · 2026Pooled it
- Simple mucinous cyst: another potential cancer precursor in the pancreas? Case report with molecular characterization and systematic review of the literature.Virchows Archiv : an international journal of pathology · 2021Pooled it
- Pancreatic Cancer Early Detection Biomarkers for High-Risk Individuals: Insights From the PRECEDE Consortium.International journal of cancer · 2026Review
- Cancer Risk After Initial Surveillance of Intraductal Papillary Mucinous Neoplasms (IPMNs): Are We Missing the Window for Prevention?Annals of surgical oncology · 2026Article
- Does ductal subtype predict outcomes after resection of IPMN-derived pancreatic cancer? An international multi-center retrospective study.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2026Article
- Metastasis-SpecificJournal of clinical medicine · 2026Article
- Hereditary Pancreatic Cancer: Genetic Risk, Surveillance Strategies, and Therapeutic Implications.International journal of molecular sciences · 2026Review
- First-in-human testing of a mutant KRAS vaccine for pancreatic cancer interception in high-risk cohorts.Cancer discovery · 2026Article
- PancreaSeq Genomic Classifier (PancreaSeq GC) Improves Pancreatic Cyst Classification and Detection of Advanced Neoplasia: A Multi-institutional Validation Study.Annals of surgical oncology · 2026Article
- Clonal evolutionary analysis reveals patterns of malignant transformation of Intraductal Papillary Mucinous Neoplasms of the pancreas.Nature communications · 2026Article
- Evidence that extra copies of chromosome 1q play a role in the early phases of pancreatic neoplasia.Science advances · 2026Article
- An oncogenic KRAS-driven secretome involving TNFα promotes niche preparation prior to pancreatic cancer onset.Molecular cancer · 2026Article
- Gamma-glutamyl transferase as a redox-gatekeeper biomarker for pancreatic cystic neoplasms: A concise roadmap from epidemiology to bedside.World journal of gastroenterology · 2026Article
- Research progress on the etiology and pathogenesis of pancreatic cancer: a narrative review.Frontiers in oncology · 2026Review
- Multi-omic profiling of intraductal papillary neoplasms of the pancreas reveals distinct patterns and potential markers of progression.Cancer cell · 2025Article
- Integrative analysis of genomic and transcriptomic data informs precancer progression in the pancreas.bioRxiv : the preprint server for biology · 2025Article
- Serum gamma-glutamyl transferase level is associated with the risk of pancreatic cystic neoplasms: A nationwide retrospective cohort study.World journal of gastroenterology · 2025Article
- Article
- Early neoplastic lesions of the pancreas: initiation, progression, and opportunities for precancer interception.The Journal of clinical investigation · 2025Review
- Drugging the 'undruggable' KRAS: breakthroughs, challenges, and opportunities in pancreatic cancer.Cancer biology & medicine · 2025Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
38 authors at 18 institutions in 11 countries.
Michaël NoëDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-5336-4508
Noushin NiknafsSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Catherine G FischerDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Wenzel M HackengDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Violeta Beleva GuthrieInstitute for Computational Medicine, Johns Hopkins University, Baltimore, MD, USA.
Waki HosodaDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Marija DebeljakDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-4865-2820
Eniko PappSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Vilmos AdleffSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
James R WhiteSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Claudio LuchiniDepartment of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy.ORCID http://orcid.org/0000-0003-4901-4908
Antonio PeaDepartment of Surgery - The Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy.
Aldo ScarpaDepartment of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy.ORCID http://orcid.org/0000-0003-1678-739X
Giovanni ButturiniDepartment of Surgery, Pederzoli Hospital, Peschiera del Garda, Italy.
Giuseppe ZamboniDepartment of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy.ORCID http://orcid.org/0000-0001-7428-4673
Paola CastelliPathology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar, Verona, Italy.
Seung-Mo HongDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-8888-6007
Shinichi YachidaDepartment of Cancer Genome Informatics, Graduate School of Medicine, Osaka University, Osaka, Japan.ORCID http://orcid.org/0000-0001-5507-4566
Nobuyoshi HiraokaDepartment of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.ORCID http://orcid.org/0000-0003-4215-4385
Anthony J GillUniversity of Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-9447-1967
Jaswinder S SamraUniversity of Sydney, Sydney, NSW, Australia.
G Johan A OfferhausDepartment of Pathology, The University Medical Center Utrecht, Utrecht, The Netherlands.
Anne HoorensDepartment of Pathology, Ghent University Hospital, Ghent, Belgium.ORCID http://orcid.org/0000-0002-0736-2034
Joanne VerheijDepartment of Pathology, Academic Medical Center, Amsterdam, The Netherlands.
Casper JansenLABPON, Laboratory for Pathology Eastern Netherlands, Hengelo, The Netherlands.
N Volkan AdsayKoc University School of Medicine, Istanbul, Turkey.
Wei JiangDepartment of Pathology, Thomas Jefferson University, Philadelphia, PA, USA.
Jordan WinterUniversity Hospitals Cleveland Medical Center and Seidman Cancer Center, Cleveland, OH, USA.
Jorge Albores-SaavedraDepartment of Pathology, Medica Sur Clinic and Foundation, Mexico City, Mexico.
Benoit TerrisService de Pathologie, AP-HP, Hôpital Cochin, Université Paris Descartes, Paris, France.
Elizabeth D ThompsonDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nicholas J RobertsDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-8709-0664
Ralph H HrubanDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-4554-5672
Rachel KarchinSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-5069-1239
Robert B ScharpfSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lodewijk A A BrosensDepartment of Pathology, The University Medical Center Utrecht, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0003-1341-8994
Victor E VelculescuDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-1195-438X
Laura D WoodDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ldwood@jhmi.edu.ORCID http://orcid.org/0000-0003-3096-652X
Johns Hopkins University · USUniversity of Verona · ITThe University of Sydney · AUAmsterdam UMC Location University of Amsterdam · NLCasa di Cura Villa Garda · ITGhent University Hospital · BEHospital Médica Sur · MXKoç University · TROspedale Sacro Cuore Don Calabria · ITRadboud University Nijmegen · NLThales (Netherlands) · NLThe University of Osaka · JPThomas Jefferson University · USTokyo National Hospital · JPUlsan College · KRUniversité Paris Cité · FRUniversity Hospitals Seidman Cancer Center · USUniversity Medical Center Utrecht · NL
Funding
Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6MTumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI JAFFEE, ELIZABETH M. · 1993 to 2022
$54.6MLarge-Scale Genetic Analyses of Human CancerR01CA121113 · NCI · JOHNS HOPKINS UNIVERSITY · PI ANAGNOSTOU, VALSAMO, VELCULESCU, VICTOR E. · 2006 to 2022
$4.3MCharacterization of the Molecular Determinants of High-Grade Dysplasia in Pancreatic Cancer Precursor LesionsK08DK107781 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI WOOD, LAURA DELONG · 2016 to 2020
$846kIntegrative Analyses to Identify Pancreatic Cancer Susceptibility GenesR00CA190889 · NCI · JOHNS HOPKINS UNIVERSITY · PI ROBERTS, NICHOLAS JASON · 2017 to 2019
$747kNCI NIH HHS P30 CA006973NCI NIH HHS P50 CA062924NCI NIH HHS R00 CA190889NCI NIH HHS R01 CA121113NIDDK NIH HHS K08 DK107781
Abstract
Intraductal papillary mucinous neoplasms (IPMNs) and mucinous cystic neoplasms (MCNs) are non-invasive neoplasms that are often observed in association with invasive pancreatic cancers, but their origins and evolutionary relationships are poorly understood. In this study, we analyze 148 samples from IPMNs, MCNs, and small associated invasive carcinomas from 18 patients using whole exome or targeted sequencing. Using evolutionary analyses, we establish that both IPMNs and MCNs are direct precursors to pancreatic cancer. Mutations in SMAD4 and TGFBR2 are frequently restricted to invasive carcinoma, while RNF43 alterations are largely in non-invasive lesions. Genomic analyses suggest an average window of over three years between the development of high-grade dysplasia and pancreatic cancer. Taken together, these data establish non-invasive IPMNs and MCNs as origins of invasive pancreatic cancer, identifying potential drivers of invasion, highlighting the complex clonal dynamics prior to malignant transformation, and providing opportunities for early detection and intervention.
Indexed as
Disease ProgressionGenomicsCarcinogenesisCell Transformation, NeoplasticExomeGene DosageHumansMutationPancreatic CystPancreatic NeoplasmsReceptor, Transforming Growth Factor-beta Type IISmad4 ProteinReceptor, Transforming Growth Factor-beta Type IISmad4 ProteinSMAD4 protein, humanTGFBR2 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.