Evidence map›Paper›PMID 32796702›Full record

ArticleInternational journal of molecular sciences2020

Vascular Remodeling in Moyamoya Angiopathy: From Peripheral Blood Mononuclear Cells to Endothelial Cells.

Francesca Tinelli, Sara Nava, Francesco Arioli, Gloria Bedini, Emma Scelzo, Daniela Lisini, Giuseppe Faragò, Andrea Gioppo, Elisa F Ciceri, Francesco Acerbi and 17 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Lipid metabolism in moyamoya disease: Emerging evidence, vascular remodeling, and therapeutic implications.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  3. Review
  4. An Overview of Genetics of Moyamoya: BeyondInternational journal of molecular sciences · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Angiopoietin-2 associates with poor prognosis in Moyamoya angiopathy.Annals of clinical and translational neurology · 2024
    Article
  9. Review
  10. Article
  11. Article
  12. Proteome Profiling of the Dura Mater in Patients with Moyamoya Angiopathy.International journal of molecular sciences · 2023
    Article
  13. Article
  14. Review
  15. Novel Multifaceted Roles for RNF213 Protein.International journal of molecular sciences · 2022
    Review
  16. The Genetic Basis of Moyamoya Disease.Translational stroke research · 2022
    Review
  17. Review
  18. Observational
  19. Cell Signaling in Neurodegeneration.International journal of molecular sciences · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 8 institutions in 3 countries.

Francesca TinelliLaboratory of Cellular Neurobiology, Neurology IX Unit, UCV, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Sara NavaLaboratory of Cellular Neurobiology, Neurology IX Unit, UCV, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Francesco ArioliLaboratory of Cellular Neurobiology, Neurology IX Unit, UCV, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.ORCID 0000-0003-3105-328X
Gloria BediniImmunology and Cell Therapy Unit, Tettamanti Research Center, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0002-3653-427X
Emma ScelzoNeurology IX Unit, UCV, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Daniela LisiniLaboratory of Cellular Neurobiology, Neurology IX Unit, UCV, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.ORCID 0000-0002-7436-8401
Giuseppe FaragòDiagnostic Imaging & Interventional Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Andrea GioppoDiagnostic Imaging & Interventional Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Elisa F CiceriDiagnostic Imaging & Interventional Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Francesco AcerbiNeurosurgical II Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Paolo FerroliNeurosurgical II Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Ignazio G VetranoNeurosurgical II Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.ORCID 0000-0003-0664-9700
Silvia EspositoDevelopmental Neurology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Veronica SalettiDevelopmental Neurology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Chiara PantaleoniDevelopmental Neurology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Federica ZibordiDepartment of Pediatric Neuroscience, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Nardo NardocciDepartment of Pediatric Neuroscience, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Maria Luisa ZeddeNeurology Unit, Stroke Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy.ORCID 0000-0001-7530-818X
Alessandro PezziniDepartment of Clinical and Experimental Sciences, Clinica Neurologica, Università degli Studi di Brescia, 25121 Brescia, Italy.
Vincenzo Di LazzaroUnit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.ORCID 0000-0002-9113-5925
Fioravante CaponeUnit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.
Maria Luisa Dell'AcquaStroke Unit, Neurology Clinic, Department of Biomedical Metabolic and Neural Sciences, Nuovo Ospedale Civile S Agostino Estense, University of Modena and Reggio Emilia, 41126 Modena, Italy.
Peter VajkoczyDepartment of Neurosurgery, Charite Universitätsmedizin, 10117 Berlin, Germany.
Elisabeth Tournier-LasserveDepartment of Genetics, Lariboisière Hospital and INSERM U1141, Paris-Diderot University, 75010 Paris, France.
Eugenio A ParatiNeurology IX Unit, UCV, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Anna BersanoNeurology IX Unit, UCV, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Laura GattiLaboratory of Cellular Neurobiology, Neurology IX Unit, UCV, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.ORCID 0000-0001-6751-5031
Fondazione IRCCS Istituto Neurologico Carlo Besta · ITUniversità Campus Bio-Medico · ITAzienda Sanitaria Unità Locale di Reggio Emilia · ITCharité - Universitätsmedizin Berlin · DEInserm · FRUniversity of Brescia · ITUniversity of Milano-Bicocca · ITUniversity of Modena and Reggio Emilia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathophysiological mechanisms of Moyamoya angiopathy (MA), which is a rare cerebrovascular condition characterized by recurrent ischemic/hemorrhagic strokes, are still largely unknown. An imbalance of vasculogenic/angiogenic mechanisms has been proposed as one possible disease aspect. Circulating endothelial progenitor cells (cEPCs) have been hypothesized to contribute to vascular remodeling of MA, but it remains unclear whether they might be considered a disease effect or have a role in disease pathogenesis. The aim of the present study was to provide a morphological, phenotypical, and functional characterization of the cEPCs from MA patients to uncover their role in the disease pathophysiology. cEPCs were identified from whole blood as CD45

Indexed as

Vascular RemodelingAdultBiomarkersCell CountChildCytokinesEndothelial CellsFemaleGene Expression RegulationHumansHuman Umbilical Vein Endothelial CellsLeukocytes, MononuclearMaleMoyamoya DiseaseNeovascularization, PhysiologicParacrine CommunicationBiomarkersCytokinesRNA, Messengerendothelial progenitor cellsMoyamoya angiopathyneovascularizationRNF213

Identifiers

PMID32796702
PMCPMC7460840
OpenAlexW3048621522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.