ArticleInternational journal of environmental research and public health2020
Estimated 24 h Urinary Sodium-to-Potassium Ratio Is Related to Renal Function Decline: A 6-Year Cohort Study of Japanese Urban Residents.
Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Are changes in the urinary sodium-to-potassium ratio associated with changes in blood pressure in a healthy population with low urinary sodium-to-potassium ratios? Eight-year follow-up results from the KOBE Study.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Prediction of future development of hypertension in the general population using urinary Na/K ratio.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Independent and combined associations of body mass index and visceral fat area with kidney function decline in a healthy Japanese urban population: a longitudinal study.BMC nephrology · 2026Article
- Association of Urinary Sodium, Potassium, and the Sodium-to-Potassium Ratio with Impaired Kidney Function Assessed with 24-H Urine Analysis.Nutrients · 2024Article
- Urinary Na/K ratio is a predictor of developing chronic kidney disease in the general population.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Sodium-to-potassium ratio and renal functional decline.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Determinants of double product: a cross-sectional study of urban residents in Japan.Environmental health and preventive medicine · 2023Article
- Physique at Birth and Cardiovascular Disease Risk Factors in Japanese Urban Residents: the KOBE Study.Journal of atherosclerosis and thrombosis · 2022Article
- Association between the urinary sodium-to-potassium ratio and renal outcomes in patients with chronic kidney disease: a prospective cohort study.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Association of Sodium, Potassium and Sodium-to-Potassium Ratio with Urine Albumin Excretion among the General Chinese Population.Nutrients · 2021Article
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16 authors.
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Abstract
The effect of the sodium-to-potassium ratio (Na/K) on renal function within the clinically normal range of renal function are limited. We investigated the effects of an estimated 24 h urinary Na/K (e24hUNa/K) on a 6-year renal function decline among 927 urban Japanese community dwellers with no history of cardiovascular diseases and medication for hypertension, diabetes, or dyslipidemia. We partitioned the subjects into quartiles according to the e24hUNa/K. The estimated glomerular filtration rate (eGFR) was calculated using the chronic kidney disease epidemiology collaboration (CKD/EPI) formula and renal function decline was defined as an absolute value at or above the third quartile of the eGFR decline rate. A multivariable logistic regression model was used for estimation. Compared with the first quartile of the e24hUNa/K, multivariable-adjusted odds ratios (ORs) for eGFR decline in the second, third, and fourth quartiles were 0.96 (95% confidence interval: 0.61-1.51), 1.06 (0.67-1.66), and 1.65 (1.06-2.57), respectively. These results were similar when the simple spot urine Na/K ratio was used in place of the e24hUNa/K. Apparently healthy urban residents with an almost within normal range mean baseline eGFR and high e24hUNa/K ratios had an increased risk for a future decline in renal function. Reducing the Na/K ratio may be important in the prevention of chronic kidney disease in its early stage.
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