Evidence map›Paper›PMID 32796640›Full record

ArticleMolecules (Basel, Switzerland)2020

Deletion of the Histone Deacetylase HdaA in Endophytic Fungus

Zhuang Ding, Haibo Zhou, Xiao Wang, Huiming Huang, Haotian Wang, Ruiyan Zhang, Zhengping Wang, Jun Han

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Anti-Candidal Marine Natural Products: A Review.Journal of fungi (Basel, Switzerland) · 2023
    Review
  11. Review
  12. Article
  13. Microorganisms · 2022
    Review
  14. Review
  15. Transcriptional Activation of Biosynthetic Gene Clusters in Filamentous Fungi.Frontiers in bioengineering and biotechnology · 2022
    Review
  16. Review
  17. Review
  18. Regulation of Secondary Metabolism in theInternational journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhuang DingInstitute of BioPharmaceutical Research, Liaocheng University, Liaocheng 252059, China.ORCID 0000-0002-0227-692X
Haibo ZhouShandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.ORCID 0000-0001-9656-6479
Xiao WangInstitute of BioPharmaceutical Research, Liaocheng University, Liaocheng 252059, China.
Huiming HuangSchool of Life Science, Liaocheng University, Liaocheng 252059, China.
Haotian WangFaculty of Pharmacy, Bengbu Medical College, Bengbu 233000, China.
Ruiyan ZhangInstitute of BioPharmaceutical Research, Liaocheng University, Liaocheng 252059, China.
Zhengping WangInstitute of BioPharmaceutical Research, Liaocheng University, Liaocheng 252059, China.
Jun HanInstitute of BioPharmaceutical Research, Liaocheng University, Liaocheng 252059, China.

Funding

Bengbu Medical College Natural Science Fund Project BYKY1768Natural Science Foundation of Shandong Province ZR2017BB077Natural Science Foundation of Shandong Province ZR2018BH043Taishan Scholar Foundation of Shandong Province 319190201
6 · The paper itself

Abstract

Epigenetic regulation plays a critical role in controlling fungal secondary metabolism. Here, we report the pleiotropic effects of the epigenetic regulator HdaA (histone deacetylase) on secondary metabolite production and the associated biosynthetic gene clusters (BGCs) expression in the plant endophytic fungus

Indexed as

Gene DeletionMultigene FamilySecondary MetabolismBiological ProductsFicusHistone DeacetylasesHL-60 CellsHumansIndole AlkaloidsK562 CellsPenicillium chrysogenumBiological ProductsHistone DeacetylasesIndole Alkaloidsendophytic fungimeleagrinmetabolic regulationPenicillium chrysogenumroquefortine

Identifiers

PMID32796640
PMCPMC7464707

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.