Evidence map›Paper›PMID 32796546›Full record

Trial reportNutrients2020

Space Flight Diet-Induced Deficiency and Response to Gravity-Free Resistive Exercise.

Shahid Baba, Ted Smith, Jason Hellmann, Aruni Bhatnagar, Kathy Carter, Alexandria Vanhoover, John Caruso

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Decoding blood fatty acids in Crimean-Congo hemorrhagic fever.Metabolomics : Official journal of the Metabolomic Society · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Effects of Low Dose Space Radiation Exposures on the Splenic Metabolome.International journal of molecular sciences · 2021
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shahid BabaEnvirome Institute, Department of Medicine, University of Louisville, Louisville, KY 40208, USA.
Ted SmithEnvirome Institute, Department of Medicine, University of Louisville, Louisville, KY 40208, USA.ORCID 0000-0003-2804-4294
Jason HellmannEnvirome Institute, Department of Medicine, University of Louisville, Louisville, KY 40208, USA.
Aruni BhatnagarEnvirome Institute, Department of Medicine, University of Louisville, Louisville, KY 40208, USA.
Kathy CarterCentral State University, Wilberforce, OH 45384, USA.
Alexandria VanhooverExercise Physiology Program, University of Louisville, Louisville, KY 40208, USA.
John CarusoExercise Physiology Program, University of Louisville, Louisville, KY 40208, USA.

Funding

TBDP30GM127607 · NIGMS · UNIVERSITY OF LOUISVILLE · PI BHATNAGAR, ARUNI · 2018 to 2022
$6.3M
Exercise-enhanced resolution of inflammationR01GM127495 · NIGMS · UNIVERSITY OF LOUISVILLE · PI HELLMANN, JASON L · 2018 to 2022
$2.5M
Kentucky Space Grant Consortium RFP-18-001NIGMS NIH HHS P30 GM127607NIGMS NIH HHS R01 GM127495
6 · The paper itself

Abstract

Immune system dysregulation is among the many adverse effects incurred by astronauts during space flights. Omega-3 fatty acids, β-alanine, and carnosine are among the many nutrients that contribute to immune system health. For space flight, crewmembers are prescribed a diet with a macronutrient composition of 55% carbohydrate, 30% fat, and 15% protein. To quantify omega-3 fatty acid, β-alanine and carnosine intakes from such a diet, and to examine each nutrient's impact on exercise performance, 21 participants adhered to the aforementioned macronutrient ratio for 14 days which was immediately followed by a workout performed on gravity-independent resistive exercise hardware. Results included daily omega-3 fatty acid intakes below the suggested dietary intake. Daily omega-3 fatty acid, β-alanine and carnosine intakes each correlated with non-significant amounts of variance from the workout's volume of work. Given the nutritional requirements to maintain immune system function and the demands of in-flight exercise countermeasures for missions of increasingly longer durations current results, in combination with previously published works, imply in-flight supplementation may be a prudent approach to help address the physiological and mental challenges incurred by astronauts on future space flights.

Indexed as

Space FlightAdultAstronautsbeta-AlanineCarnosineCross-Over StudiesDeficiency DiseasesDietDiet SurveysExerciseFatty Acids, Omega-3FemaleHumansImmune SystemMaleNutritional Requirementsbeta-AlanineCarnosineFatty Acids, Omega-3ergogenicimmune systemmicrogravitynutrition

Identifiers

PMID32796546
PMCPMC7468946

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.