Evidence map›Paper›PMID 32796181›Full record

ReviewCritical care medicine2020

Principles Guiding Nonpandemic Critical Care Research During a Pandemic.

Deborah J Cook, Michelle E Kho, Eric H Duan, Waleed Alhazzani, Alyson Takaoka, France J Clarke, Nicole Zytaruk, Meredith Vanstone

Abstract readComparative StudyReview

PubMed Full text at PMC Publisher

In one paragraph

Review in Critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it

0cells of the map it votes in

11citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

Proton pump inhibitors in invasively ventilated patients with SARS-CoV-2: a substudy of the re-evaluating the inhibition of stress erosions trial.BMJ open · 2026
Trial
Protocol implementation during the COVID-19 pandemic: experiences from a randomized trial of stress ulcer prophylaxis.BMC medical research methodology · 2024
Trial
Research interrupted: applying the CONSERVE 2021 Statement to a randomized trial of rehabilitation during critical illness affected by the COVID-19 pandemic.Trials · 2022
Trial
Barriers, Solutions, and Opportunities for Adapting Critical Care Clinical Trials in the COVID-19 Pandemic.JAMA network open · 2024
Article
REVISE:BMJ open · 2023
Article
Critical care and pandemic preparedness and response.British journal of anaesthesia · 2023
Review
BMJ open · 2023
Article
Multistudy Research Operations in the ICU: An Interprofessional Pandemic-Informed Approach.Critical care explorations · 2022
Article
Effectiveness of methylprednisolone therapy in patients with a high-risk common type of COVID-19 pneumonia: a retrospective cohort study.Clinical and experimental medicine · 2022
Article
Undertaking Rehabilitation Research During the COVID-19 Pandemic: Emergent Strategies From a Trainee-Faculty Workshop.Frontiers in rehabilitation sciences · 2022
Article
Post-exposure prophylaxis or pre-emptive therapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): study protocol for a pragmatic randomized-controlled trial.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2020
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Deborah J CookDivision of Critical Care, Department of Medicine, Faculty of Health Sciences, McMaster University; Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University; and Department of Critical Care, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.

Michelle E KhoDepartment of Physiotherapy, School of Rehabilitation Science, Faculty of Health Sciences, McMaster University; and Physiotherapy Department, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.

Eric H DuanDivision of Critical Care, Department of Medicine, Faculty of Health Sciences, McMaster University; Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University; and Department of Critical Care, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada, Division of Critical Care, Niagara Health, St. Catharines, ON, Canada.

Waleed AlhazzaniDivision of Critical Care, Department of Medicine, Faculty of Health Sciences, McMaster University; Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University; and, Department of Critical Care, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.

Alyson TakaokaDepartment of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.

France J ClarkeDepartment of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.

Nicole ZytarukDepartment of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.

Meredith VanstoneDepartment of Family Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo describe the importance of critical care clinical research that is not pandemic-focused during pandemic times; outline principles to assist in the prioritization of nonpandemic research during pandemic times; and propose a guiding framework for decisions about whether, when and how to continue nonpandemic research while still honoring the moral and scientific imperative to launch research that is pandemic-focused. DESIGN/DATA SOURCES: Using in-person, email, and videoconference exchanges, we convened an interprofessional clinical research group, conducted a literature review of empirical studies, ethics documents and expert commentaries (2010 to present), and viewed traditional and social media posts (March 2020 to May 2020). Stakeholder consultation involved scientific, ethics, clinical, and administrative leaders.

settingClinical research in the ICU. PATIENTS: Patients with and without coronavirus disease 2019.

interventionsNone. MEASUREMENTS AND MAIN

resultsWhile clinical research should be prioritized to advantage patients with coronavirus disease 2019 in order to care for affected patients, it ideally would not unduly disadvantage patients without coronavirus disease 2019. Thus, timely, rigorous, relevant, and ethical clinical research is needed to improve the care and optimize outcomes for both patients with and without coronavirus disease 2019, acknowledging how many studies that are not exclusively focused on coronavirus disease 2019 remain relevant to patients with coronavirus disease 2019. Considerations to continue nonpandemic-focused research include the status of the pandemic, local jurisdictional guidance, capacity and safety of bedside and research personnel, disposition of patients already enrolled in nonpandemic studies, analyzing characteristics of each nonpandemic-focused study, research oversight, and final reporting requirements.

conclusionsDeliberation about continuing nonpandemic research should use objective, transparent criteria considering several aspects of the research process such as bedside and research staff safety, infection control, the informed consent model, protocol complexity, data collection, and implementation integrity. Decisions to pause or pursue nonpandemic research should be proportionate, transparent, and revisited as the pandemic abates.

Indexed as

Practice Guidelines as TopicBiomedical ResearchCoronavirus InfectionsCOVID-19Critical CareCritical IllnessFemaleGlobal HealthHumansInfection ControlMalePandemicsPneumonia, ViralResearch DesignSafety Management

Identifiers

PMID32796181

DOI10.1097/CCM.0000000000004538

PMCPMC7437406

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.