ArticleAJNR. American journal of neuroradiology2020
MRI Findings at Term-Corrected Age and Neurodevelopmental Outcomes in a Large Cohort of Very Preterm Infants.
Article in AJNR. American journal of neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Association between Term Equivalent Brain Magnetic Resonance Imaging and 2-Year Outcomes in Extremely Preterm Infants: A Report from the Preterm Erythropoietin Neuroprotection Trial Cohort.The Journal of pediatrics · 2021Trial
- MRI and proton MR spectroscopy in neonatal hypoxic-ischemic encephalopathy: a comprehensive imaging review.Japanese journal of radiology · 2026Review
- Reassessing bronchopulmonary dysplasia definitions: association between severity grading and brain injury on term-equivalent age MRI.Translational pediatrics · 2026Article
- Magnetic Resonance Imaging of the Neonatal Brain: Modalities, Scoring Systems, and Clinical Applications.Bioengineering (Basel, Switzerland) · 2026Review
- Very Preterm Infant Retinal Microanatomy at 36 Weeks' Postmenstrual Age and 2-Year Neurodevelopment.JAMA ophthalmology · 2026Article
- Opioid exposure on the preterm brain: qualitative and quantitative MRI analysis.Intensive care medicine. Paediatric and neonatal · 2026Article
- Cerebellar hemorrhages in very preterm infants: presence, involvement of the dentate nucleus, and cerebellar hypoplasia are associated with adverse cognitive outcomes.European radiology · 2025Article
- CMRI-detected brain injuries and clinical key risk factors associated with adverse neurodevelopmental outcomes in very preterm infants.Scientific reports · 2025Article
- A Low-Field MRI Dataset For Spatiotemporal Analysis of Developing Brain.Scientific data · 2025Article
- Article
- Brain 3T magnetic resonance imaging in neonates: features and incidental findings from a research cohort enriched for preterm birth.Archives of disease in childhood. Fetal and neonatal edition · 2024Article
- Synthetic magnetic resonance-based relaxometry and brain volume: cutoff values for predicting neurocognitive outcomes in very preterm infants.Pediatric radiology · 2024Article
- Incidence of brain injuries in a large cohort of very preterm and extremely preterm infants at term-equivalent age: results of a single tertiary neonatal care center over 10 years.European radiology · 2024Article
- On Behalf of Serial Imaging in Preterm Infants.AJNR. American journal of neuroradiology · 2024Article
- Neurodevelopmental Outcome after Culture-Proven or So-Called Culture-Negative Sepsis in Preterm Infants.Journal of clinical medicine · 2024Article
- Effects of two-stage preterm formulas on growth, nutritional biomarkers, and neurodevelopment in preterm infants.Frontiers in pediatrics · 2024Article
- Regional cerebral oxygen saturation variability and brain injury in preterm infants.Frontiers in pediatrics · 2024Article
- Neurodevelopmental Outcome and Neuroimaging of Very Low Birth Weight Infants from an Italian NICU Adopting the Family-Centered Care Model.Children (Basel, Switzerland) · 2023Article
- Relationship of early brain growth pattern measured by ultrasound with neurological outcome at two years of age in very low birth weight infants.European journal of pediatrics · 2023Article
- Development of neonatal-specific sequences for portable ultralow field magnetic resonance brain imaging: a prospective, single-centre, cohort study.EClinicalMedicine · 2023Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
background and purposeBrain MR imaging at term-equivalent age is a useful tool to define brain injury in preterm infants. We report pragmatic clinical radiological assessment of images from a large unselected cohort of preterm infants imaged at term and document the spectrum and frequency of acquired brain lesions and their relation to outcomes at 20 months. MATERIALS AND
methodsInfants born at <33 weeks' gestation were recruited from South and North West London neonatal units and imaged in a single center at 3T at term-equivalent age. At 20 months' corrected age, they were invited for neurodevelopmental assessment. The frequency of acquired brain lesions and the sensitivity, specificity, and negative and positive predictive values for motor, cognitive, and language outcomes were calculated, and corpus callosal thinning and ventricular dilation were qualitatively assessed.
resultsFive hundred four infants underwent 3T MR imaging at term-equivalent age; 477 attended for assessment. Seventy-six percent of infants had acquired lesions, which included periventricular leukomalacia, hemorrhagic parenchymal infarction, germinal matrix-intraventricular hemorrhage, punctate white matter lesions, cerebellar hemorrhage, and subependymal cysts. All infants with periventricular leukomalacia, and 60% of those with hemorrhagic parenchymal infarction had abnormal motor outcomes. Routine 3T MR imaging of the brain at term-equivalent age in an unselected preterm population that demonstrates no focal lesion is 45% sensitive and 61% specific for normal neurodevelopment at 20 months and 17% sensitive and 94% specific for a normal motor outcome.
conclusionsAcquired brain lesions are common in preterm infants routinely imaged at term-equivalent age, but not all predict an adverse neurodevelopmental outcome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.