Evidence map›Paper›PMID 32796083›Full record

ArticleRNA (New York, N.Y.)2020

3'READS + RIP defines differential Staufen1 binding to alternative 3'UTR isoforms and reveals structures and sequence motifs influencing binding and polysome association.

Dinghai Zheng, Hana Cho, Wei Wang, Xavier Rambout, Bin Tian, Lynne E Maquat

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Dinghai Zheng *Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey 07103, USA.
Hana Cho *Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA.ORCID 0000-0002-7520-7108
Wei Wang *Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey 07103, USA.
Xavier RamboutDepartment of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA.
Bin TianDepartment of Microbiology, Biochemistry, and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey 07103, USA.
Lynne E MaquatDepartment of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA.
University of Rochester · USRutgers, The State University of New Jersey · USThe Wistar Institute · US

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9M
Regulation of Alternative Cleavage and PolyadenylationR01GM084089 · NIGMS · WISTAR INSTITUTE · PI TIAN, BIN · 2008 to 2023
$6.7M
Regulation of Normal and Defective Human GenesR37GM074593 · NIGMS · UNIVERSITY OF ROCHESTER · PI MAQUAT, LYNNE E · 2014 to 2023
$4.8M
Regulation and Functions of 3'UTRs in Cellular StressR01GM129069 · NIGMS · WISTAR INSTITUTE · PI TIAN, BIN · 2018 to 2021
$1.5M
Acquisition of a Typhoon FLA 9500 Laser Scanning ImagerS10OD021489 · OD · UNIVERSITY OF ROCHESTER · PI BUTLER, JAMES SCOTT · 2017 to 2017
$130k
American Heart Association-American Stroke Association 18POST33960339NCI NIH HHS P30 CA010815NIGMS NIH HHS R01 GM084089NIGMS NIH HHS R01 GM129069NIGMS NIH HHS R37 GM074593NIH HHS S10 OD021489
6 · The paper itself

Abstract

Staufen1 (STAU1) is an RNA-binding protein (RBP) that interacts with double-stranded RNA structures and has been implicated in regulating different aspects of mRNA metabolism. Previous studies have indicated that STAU1 interacts extensively with RNA structures in coding regions (CDSs) and 3'-untranslated regions (3'UTRs). In particular, duplex structures formed within 3'UTRs by inverted-repeat

Indexed as

3' Untranslated RegionsAlternative SplicingAlu ElementsCytoskeletal ProteinsGene Expression ProfilingGene Knockout TechniquesHEK293 CellsHigh-Throughput Nucleotide SequencingHumansImmunoprecipitationMolecular ConformationPolyribosomesRNA-Binding MotifsRNA-Binding ProteinsRNA, Messenger3' Untranslated RegionsCytoskeletal ProteinsRNA-Binding ProteinsRNA, MessengerSTAU1 protein, human3′-untranslated regionsalternative polyadenylationAlu elementsmRNA isoformsmRNA-polysome associationStaufen

Identifiers

PMID32796083
PMCPMC7566578
OpenAlexW3048782164

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.