Evidence map›Paper›PMID 32796074›Full record

ArticleJournal of virology2020

Two Genetic Differences between Closely Related Zika Virus Strains Determine Pathogenic Outcome in Mice.

Derek L Carbaugh, Shuntai Zhou, Wes Sanders, Nathaniel J Moorman, Ronald Swanstrom, Helen M Lazear

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Zika Virus Infection of PregnantJournal of virology · 2021
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Derek L CarbaughDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-5721-7097
Shuntai ZhouUNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-8353-386X
Wes SandersDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Nathaniel J MoormanDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Ronald SwanstromDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Helen M LazearDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA helen.lazear@med.unc.edu.ORCID 0000-0002-8649-4579
University of North Carolina at Chapel Hill · US

Funding

Molecular Biology of Viral Diseases Predoctoral Training GrantT32AI007419 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark T Heise, CARY A MOODY · 1993 to 2026
$4.7M
HIV Evolution Defines Virus-Host/Drug Interactions In Viremic and Aviremic PeopleR01AI140970 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ronald I Swanstrom, Shuntai Zhou · 2018 to 2026
$4.1M
The role of Interferon lambda signaling in flavivirus transmission and pathogenesis at the maternal-fetal interfaceR01AI139512 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LAZEAR, HELEN · 2019 to 2023
$1.9M
Molecular Characterization of Functional RNA Structures in the ZIKV genomeR21AI137887 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HEISE, MARK T, MOORMAN, NATHANIEL J · 2018 to 2019
$424k
Viral and host determinants of Zika virus tissue tropismR21AI129431 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LAZEAR, HELEN · 2017 to 2018
$418k
NIAID NIH HHS R01 AI139512NIAID NIH HHS R01 AI140970NIAID NIH HHS R21 AI129431NIAID NIH HHS R21 AI137887NIAID NIH HHS T32 AI007419
6 · The paper itself

Abstract

Recent Zika virus (ZIKV) outbreaks and unexpected clinical manifestations of ZIKV infection have prompted an increase in ZIKV-related research. Here, we identify two strain-specific determinants of ZIKV virulence in mice. We found that strain H/PF/2013 caused 100% lethality in

Indexed as

Genetic VariationViral ProteinsZika VirusZika Virus InfectionA549 CellsAnimalsChlorocebus aethiopsFemaleHumansInterferon gamma ReceptorMiceMice, KnockoutReceptor, Interferon alpha-betaReceptors, InterferonSpecies SpecificityVero CellsIfnar1 protein, mouseInterferon gamma ReceptorReceptor, Interferon alpha-betaReceptors, InterferonViral ProteinsflavivirusIFNAR mousestrain differencesZika virus

Identifiers

PMID32796074
PMCPMC7527068
OpenAlexW3048388644

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.