ArticleArchives of disease in childhood. Fetal and neonatal edition2021
Size at birth, growth trajectory in early life, and cardiovascular and metabolic risks in early adulthood: EPICure study.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Socioeconomic disparities in the postnatal growth of preterm infants: a systematic review.Pediatric research · 2025Pooled it
- Breastfeeding supports growth in small for gestational age infants: A systematic review and meta-analysis.Acta paediatrica (Oslo, Norway : 1992) · 2025Pooled it
- Gestational age at birth and body size from infancy through adolescence: An individual participant data meta-analysis on 253,810 singletons in 16 birth cohort studies.PLoS medicine · 2023Pooled it
- The Impact of Early-Life Growth on Long-Term Cardiometabolic and Neurocognitive Outcomes in High-Income Countries: A Neglected Public Health Problem.Nutrition reviews · 2026Review
- Comparison of early growth and development in very preterm children in the Netherlands between the 1980s and 2000s.BMC pediatrics · 2026Article
- Bronchopulmonary dysplasia and extremely preterm birth: time for a broader perspective on long-term outcomes.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Bibliometric analysis of reviews of outcomes for adults with a complex perinatal history.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Associations of growth trajectories from birth to two years of age with adolescent blood pressure: the mediating role of current BMI in the follow-up of an antenatal micronutrient supplementation trial.European journal of pediatrics · 2026Observational
- Cardio-Metabolic Risk in Adults Born Preterm: A Narrative Review.Journal of clinical medicine · 2025Review
- Extremely preterm infants with adverse neurological outcome present more frequently impaired right ventricular performance.Pediatric research · 2025Observational
- Early life factors and variation in adult kidney function in the Swedish LifeGene cohort.Scientific reports · 2025Article
- Improving growth in preterm infants through nutrition: a practical overview.Frontiers in nutrition · 2024Review
- Prematurity and Low Birth Weight and Their Impact on Childhood Growth Patterns and the Risk of Long-Term Cardiovascular Sequelae.Children (Basel, Switzerland) · 2023Review
- [Association between different growth patterns and metabolic syndrome in children and adolescents aged 7 to 17 years].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
- Growth from infancy to adulthood and associations with cardiometabolic health in individuals born extremely preterm.The Lancet regional health. Western Pacific · 2023Article
- Growth During Infancy After Extremely Preterm Birth: Associations with Later Neurodevelopmental and Health Outcomes.The Journal of pediatrics · 2023Article
- Application of growth modeling to assess the impact of hospital-based phthalate exposure on preterm infant growth parameters during the neonatal intensive care unit hospitalization.The Science of the total environment · 2022Article
- A Scoping Review: Urinary Markers of Metabolic Maturation in Preterm Infants and Future Interventions to Improve Growth.Nutrients · 2022Article
- Growth in extremely preterm children born in England in 1995 and 2006: the EPICure studies.Archives of disease in childhood. Fetal and neonatal edition · 2022Article
- Extreme prematurity: Risk and resiliency.Current problems in pediatric and adolescent health care · 2022Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo investigate whether size at birth and growth trajectories in infancy and childhood are associated with determinants of cardiovascular and metabolic risks in young adults born extremely preterm (EP, <26 weeks of gestation).
methodsWe used longitudinal data from the EPICure study of 129 EP survivors up to 19 years in the UK and Ireland in 1995. Determinants of cardiovascular and metabolic risks at 19 years included the presence of metabolic syndrome, body mass index (BMI) and systolic blood pressure (SBP). Predictors were birth weight for gestation and gain in weight z-scores in the following periods: birth-postmenstrual age of 40 weeks (term), infancy (term-2.5 years), early childhood (2.5-6.0 years) and late childhood (6-11 years).
resultsMetabolic syndrome was present in 8.7% of EP participants at 19 years. Compared with subjects without metabolic syndrome, those with metabolic syndrome tended to have a smaller size at birth (difference in means: -0.55 SD, 95% CI -1.10 to 0.01, p=0.053) and a greater increase in weight z-scores from term to 2.5 years (difference in means: 1.00 SD, 95% CI -0.17 to 2.17, p=0.094). BMI at 19 years was positively related to growth from 2.5 to 6.0 years ( β : 1.03, 95% CI 0.31 to 1.75, p=0.006); an inverse association with birthweight z-scores was found in the lower socioeconomic status group ( β : -1.79, 95% CI -3.41 to -0.17, p=0.031). Central SBP was positively related to growth from 2.5 to 6.0 years ( β : 1.75, 95% CI 0.48 to 3.02, p=0.007).
conclusionSize at EP birth and increased catch-up in weight from 2.5 to 6.0 years were associated with BMI and central SBP in early adulthood.
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