ArticleNeuroImage. Clinical2020
Bedside EEG predicts longitudinal behavioural changes in disorders of consciousness.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Research hotspots and trends in the application of electroencephalography for assessment of disorders of consciousness: a bibliometric analysis.Frontiers in neurology · 2024Pooled it
- Modulation of cortical functional connectivity and spectrum with transcranial focused ultrasound in chronic disorders of consciousness: a case report.Frontiers in psychiatry · 2026Article
- Development of an exploratory mismatch negativity-based prognostic nomogram for consciousness recovery in patients with prolonged disorders of consciousness: a derivation study.BMC neurology · 2025Article
- Temporal network instability and low-frequency overconnectivity underlie disorders of consciousness in severe brain injury.Scientific reports · 2025Article
- Individual trajectories for recovery of neocortical activity in disorders of consciousness.PLoS computational biology · 2025Article
- Functional neuroimaging in disorders of consciousness: towards clinical implementation.Brain : a journal of neurology · 2025Review
- Clinical Diagnostic and Prognostic Value of Residual Language Learning Ability in Patients with Disorders of Consciousness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Motor imagery-based brain-computer interface for differential diagnosis in prolonged disorders of consciousness.Frontiers in human neuroscience · 2025Article
- [Applications and prospects of electroencephalography technology in neurorehabilitation assessment and treatment].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Review
- Family caregivers' sense-making of the results of functional neurodiagnostics for patients with Prolonged Disorders of Consciousness.Neuropsychological rehabilitation · 2024Article
- Article
- How well do neural signatures of resting-state EEG detect consciousness? A large-scale clinical study.Human brain mapping · 2024Review
- Evolutionary origin of alpha rhythms in vertebrates.Frontiers in behavioral neuroscience · 2024Review
- Neurophysiological and Psychometric Outcomes in Minimal Consciousness State after Advanced Audio-Video Emotional Stimulation: A Retrospective Study.Brain sciences · 2023Article
- Behavioral scales variability in patients with prolonged disorders of consciousness.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Neural coding of autonomic functions in different states of consciousness.Journal of neuroengineering and rehabilitation · 2023Observational
- Understanding, detecting, and stimulating consciousness recovery in the ICU.Acta neurochirurgica · 2023Review
- EEG microstate changes during hyperbaric oxygen therapy in patients with chronic disorders of consciousness.Frontiers in neuroscience · 2023Article
- Article
- Stimulation-related modifications of evolving functional brain networks in unresponsive wakefulness.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Providing an accurate prognosis for prolonged disorder of consciousness (pDOC) patients remains a clinical challenge. Large cross-sectional studies have demonstrated the diagnostic and prognostic value of functional brain networks measured using high-density electroencephalography (hdEEG). Nonetheless, the prognostic value of these neural measures has yet to be assessed by longitudinal follow-up. We address this gap by assessing the utility of hdEEG to prognosticate long-term behavioural outcome, employing longitudinal data collected from a cohort of patients assessed systematically with resting hdEEG and the Coma Recovery Scale-Revised (CRS-R) at the bedside over a period of two years. We used canonical correlation analysis to relate clinical (including CRS-R scores combined with demographic variables) and hdEEG variables to each other. This analysis revealed that the patient's age, and the hdEEG theta band power and alpha band connectivity, contributed most significantly to the relationship between hdEEG and clinical variables. Further, we found that hdEEG measures recorded at the time of assessment augmented clinical measures in predicting CRS-R scores at the next assessment. Moreover, the rate of hdEEG change not only predicted later changes in CRS-R scores, but also outperformed clinical measures in terms of prognostic power. Together, these findings suggest that improvements in functional brain networks precede changes in behavioural awareness in pDOC. We demonstrate here that bedside hdEEG assessments conducted at specialist nursing homes are feasible, have clinical utility, and can complement clinical knowledge and systematic behavioural assessments to inform prognosis and care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.