Evidence map›Paper›PMID 32795915›Full record

ArticleiScience2020

Glioblastoma-Derived Extracellular Vesicles Facilitate Transformation of Astrocytes via Reprogramming Oncogenic Metabolism.

Ailiang Zeng, Zhiyun Wei, Rosalia Rabinovsky, Hyun Jung Jun, Rachid El Fatimy, Evgeny Deforzh, Ramil Arora, Yizheng Yao, Shun Yao, Wei Yan and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 59 citations in OpenAlex.

  1. Review
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  10. Breaking Down Glioma-Microenvironment Crosstalk.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025
    Review
  11. Review
  12. Article
  13. Article
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  15. Regulation of autophagy by non-coding RNAs in human glioblastoma.Medical oncology (Northwood, London, England) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Ailiang ZengDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Zhiyun WeiDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China. Electronic address: zwei@bwh.harvard.edu.
Rosalia RabinovskyDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Hyun Jung JunCancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
Rachid El FatimyDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Evgeny DeforzhDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Ramil AroraDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Yizheng YaoDepartment of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Shun YaoDepartment of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Center for Pituitary Tumor Surgery, Department of Neurosurgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510062, China.
Wei YanDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Erik J UhlmannDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Alain CharestCancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Yongping YouDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Anna M KrichevskyDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: akrichevsky@bwh.harvard.edu.
Brigham and Women's Hospital · USBeth Israel Deaconess Medical Center · USJiangsu Province Hospital · CN

Funding

Developing miR-10b targeting for glioblastomaR01CA215072 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI KRICHEVSKY, ANNA M. · 2018 to 2022
$2.0M
Uncovering exRNA and protein determinants of secreted vesicle heterogeneity by flow cytometric purification of vesicle subsets from cells and plasmaUG3CA241685 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CHAREST, ALAIN, COFFEY, ROBERT J. · 2019 to 2020
$1.0M
NCI NIH HHS R01 CA215072NCI NIH HHS UG3 CA241685
6 · The paper itself

Abstract

Glioblastoma (GBM) may arise from astrocytes through a multistep process involving a progressive accumulation of mutations. We explored whether GBM-derived extracellular vesicles (EVs) may facilitate neoplastic transformation and malignant growth of astrocytes. We utilized conditioned media (CM) of cultured glioma cells, its sequential filtration, diverse cell-based assays, RNA sequencing, and metabolic assays to compare the effects of EV-containing and EV-depleted CM. GBM EVs facilitated the neoplastic growth of pre-transformed astrocytes but not normal human or mouse astrocytes. They induced proliferation, self-renewal, and colony formation of pre-transformed astrocytes and enhanced astrocytoma growth in a mouse allograft model. GBM EVs appear to reprogram astrocyte metabolism by inducing a shift in gene expression that may be partly associated with EV-mediated transfer of full-length mRNAs encoding ribosomal proteins, oxidative phosphorylation, and glycolytic factors. Our study suggests an EV/extracellular RNA (exRNA)-mediated mechanism that contributes to astrocyte transformation via metabolic reprograming and implicates horizontal mRNA transfer.

Indexed as

Biological SciencesCancerCell Biology

Identifiers

PMID32795915
PMCPMC7424213
OpenAlexW3046072797

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.