ArticleMedical hypotheses2020
Apparent difference in fatalities between Central Europe and East Asia due to SARS-COV-2 and COVID-19: Four hypotheses for possible explanation.
Article in Medical hypotheses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46 citing papers in PubMed.
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- Natural selection exerted by historical coronavirus epidemic(s): comparative genetic analysis in China Kadoorie Biobank and UK Biobank.BMC genomics · 2025Article
- The role of inflammatory gene polymorphisms in severe COVID-19: a review.Virology journal · 2024Review
- Residual Lung Abnormalities in Survivors of Severe or Critical COVID-19 at One-Year Follow-Up Computed Tomography: A Narrative Review Comparing the European and East Asian Experiences.Tomography (Ann Arbor, Mich.) · 2023Review
- Insight into the liver dysfunction in COVID-19 patients: Molecular mechanisms and possible therapeutic strategies.World journal of gastroenterology · 2023Review
- Health system characteristics and COVID-19 performance in high-income countries.BMC health services research · 2023Article
- Blood filtering system for COVID-19 management: novel modality of the cytokine storm therapeutics.Frontiers in immunology · 2023Review
- Covid-19 mortality and local burden of infectious diseases: A worldwide country-by-country analysis.Journal of infection and public health · 2022Article
- Serum cystatin C and CRP are early predictive biomarkers for emergence of hypoxia in COVID-19.The American journal of the medical sciences · 2022Article
- European Governments' Responses to the COVID-19 Pandemic during the First Wave: Resetting Governance Systems to Cope More Effectively with Future Shocks.Applied spatial analysis and policy · 2022Article
- Significance of hemogram-derived ratios for predicting in-hospital mortality in COVID-19: A multicenter study.Health science reports · 2022Article
- COVID-19 in patients with cancer: first report of the ESMO international, registry-based, cohort study (ESMO-CoCARE).ESMO open · 2022Article
- The economics of stop-and-go epidemic control.Socio-economic planning sciences · 2022Article
- Age dependence of the natural history of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): an analysis of Diamond Princess data.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Article
- Response kinetics of different classes of antibodies to SARS-CoV2 infection in the Japanese population: The IgA and IgG titers increased earlier than the IgM titers.International immunopharmacology · 2022Article
- Post-acute COVID-19 syndrome in patients after 12 months from COVID-19 infection in Korea.BMC infectious diseases · 2022Article
- Premature mortality attributable to COVID-19: potential years of life lost in 17 countries around the world, January-August 2020.BMC public health · 2022Article
- Complementary Effects of Virus Population Are Required for Efficient Virus Infection.Frontiers in microbiology · 2022Article
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2 authors.
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Abstract
The comparison of the numbers of cases and deaths due to SARS-CoV-2/COVID-19 shows that people in Central Europe are much more affected than people in East Asia where the disease originally occurred. Trying to explain this difference, this communication presents four hypotheses that propose the following reasons for the observed findings: 1) Differences in social behaviors and cultures of people in the two regions; 2) Possible outbreak of virulent viruses in Central Europe due to multiple viral infection, and the involvement of immuno-virological factors associated with it, 3) Possibility of corona resistance gene mutation occurring among East Asians as a result of long-term co-evolution of virus and host, and 4) possible involvement of hygienic factors. Direct or indirect supportive evidences for each one of our hypotheses are presented and experimental approaches for their evaluation are discussed. Finally, we suggest that the dynamics of the pandemic also shows that the problems of the new coronavirus can be overcome due to people's awareness of the epidemics, rational viral diagnostics and a high level of medical care.
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