ArticleDiagnostic microbiology and infectious disease2020
False-positive SARS-CoV-2 serology in 3 children with Kawasaki disease.
Article in Diagnostic microbiology and infectious disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 17 citations in OpenAlex.
- Serological Assays Reveal No Evidence of Natural SARS-CoV-2 Infection in US Cattle.Microorganisms · 2025Article
- A false positive serology test of SARS‑CoV‑2 in a patient with Waldenström's macroglobulinemia: A case report.Experimental and therapeutic medicine · 2023Article
- Pediatric inflammatory multisystem disease in children with COVID-19.Acta bio-medica : Atenei Parmensis · 2021Article
- Clinical Characteristics and Transmission of COVID-19 in Children and Youths During 3 Waves of Outbreaks in Hong Kong.JAMA network open · 2021Article
- An Analysis Review of Detection Coronavirus Disease 2019 (COVID-19) Based on Biosensor Application.Sensors (Basel, Switzerland) · 2020Review
- The Utility of Specific Antibodies Against SARS-CoV-2 in Laboratory Diagnosis.Frontiers in microbiology · 2020Review
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Authors and funding
21 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKawasaki disease (KD) is an acute febrile and eruptive disease with systemic vasculitis predominantly affecting young East Asian children. Recent reports showed that children with KD-like disease from KD low prevalence regions had positive SARS-CoV-2 serology despite a negative SARS-CoV-2 polymerase chain reaction (PCR) in respiratory samples.
objectivesTo describe 3 pediatric Kawasaki Disease patients with false positive SARS-CoV-2 serology. STUDY
designWe retrospectively recruited children with KD diagnosed during the COVID-19 outbreak in Hong Kong. Clinical characteristics and laboratory test results including SARS-CoV-2 PCR results were retrieved. We performed a microparticle-based immunoassay for the detection of IgG against nucleoprotein (NP) and spike protein receptor binding domain (RBD), and a microneutralization assay for the detection of neutralizing antibodies.
resultsThree Chinese children with typical KD were identified. They had no epidemiological links with COVID-19 patients and tested negative for SARS-CoV-2 NPA PCR. They were treated with IVIG and aspirin, and were discharged without complications. Subsequently 2 of them were tested positive against anti-RBD and anti-NP antibodies and 1 was tested positive against anti- RBD antibodies. However, microneutralization assay showed that neutralizing antibodies were absent, suggesting a false-positive IgG result.
conclusionDetection of neutralizing antibodies is recommended to confirm previous SARS-CoV-2 infection in IgG-positive but PCR-negative patients.
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