Evidence map›Paper›PMID 32795414›Full record

ArticleCell2020

Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.

Ayuko Hoshino, Han Sang Kim, Linda Bojmar, Kofi Ennu Gyan, Michele Cioffi, Jonathan Hernandez, Constantinos P Zambirinis, Gonçalo Rodrigues, Henrik Molina, Søren Heissel and 107 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 760 papers.

0numbers the graph read from it
0cells of the map it votes in
760citing papers in PubMed
57.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

760 citing papers in PubMed, 1,200 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. MVB Maturation Responsive to KRASJournal of extracellular vesicles · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

700 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

117 authors at 20 institutions in 9 countries.

Ayuko HoshinoChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan; Japan Science and Technology Agency, PRESTO, Tokyo, Japan. Electronic address: ayukohoshino@bio.titech.ac.jp.
Han Sang KimChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Yonsei Cancer Center, Division of Medical Oncology, Department of Internal Medicine, Brain Korea 21 Plus Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea.
Linda BojmarChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden; Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Uppsala, Sweden.
Kofi Ennu GyanChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Tri-Institutional PhD Program in Computational Biology and Medicine, New York, NY, USA.
Michele CioffiChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Jonathan HernandezChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD USA.
Constantinos P ZambirinisChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Gonçalo RodriguesChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Graduate Program in Areas of Basic and Applied Biology, Abel Salazar Biomedical Sciences Institute, University of Porto, Porto, Portugal.
Henrik MolinaProteomics Resource Center, The Rockefeller University, New York, NY, USA.
Søren HeisselProteomics Resource Center, The Rockefeller University, New York, NY, USA.
Milica Tesic MarkProteomics Resource Center, The Rockefeller University, New York, NY, USA.
Loïc SteinerChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland.
Alberto Benito-MartinChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Serena LucottiChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Angela Di GiannataleChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Department of Pediatric Haematology/Oncology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Katharine OfferChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Miho NakajimaChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Caitlin WilliamsChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Laura NoguésChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Microenvironment and Metastasis Laboratory, Department of Molecular Oncology, Spanish National Cancer Research Center (CNIO), Madrid, Spain.
Fanny A Pelissier VatterChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Ayako HashimotoChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan; Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Alexander E DaviesDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
Daniela FreitasChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; i3S-Institute for Research and Innovation in Health, University of Porto, Rua Alfredo Allen 208, Porto, Portugal.
Candia M KenificChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Yonathan ArarsoChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Weston BuehringChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Pernille LauritzenChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Yusuke OgitaniChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Kei SugiuraSchool of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Naoko TakahashiSchool of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
Maša AlečkovićDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Kayleen A BaileyChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Joshua S JolissantChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Huajuan WangChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Ashton HarrisChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
L Miles SchaefferChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Guillermo García-SantosChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Department of General and Gastrointestinal Surgery, Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain.
Zoe PosnerChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Vinod P BalachandranHepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Yasmin KhakooDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
G Praveen RajuDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Avigdor ScherzDepartment of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel.
Irit SagiDepartment of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
Ruth Scherz-ShouvalDepartment of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Yosef YardenDepartment of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
Moshe OrenDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Mahathi MalladiDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mary PetriccioneDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kevin C De BragancaDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Maria DonzelliDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Cheryl FischerDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Stephanie VitolanoDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Geraldine P WrightDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lee GanshawDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mariel MarranoDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Amina AhmedDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Joe DeStefanoDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Enrico DanzerDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Pediatric Surgical Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Michael H A RoehrlHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Norman J LacayoLucile Packard Children's Hospital Stanford, Stanford, CA, USA.
Theresa C VincentDepartment of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Uppsala, Sweden; Department of Microbiology, New York University School of Medicine, New York, NY, USA.
Martin R WeiserColorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mary S BradyDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Paul A MeyersDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Leonard H WexlerDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Srikanth R AmbatiDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Alexander J ChouDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Emily K SlotkinDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Shakeel ModakDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Stephen S RobertsDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ellen M BasuDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Daniel DiolaitiPerlmutter Cancer Center, New York University Langone Health, New York, NY, USA.
Benjamin A KrantzPerlmutter Cancer Center, New York University Langone Health, New York, NY, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Fatima CardosoBreast Unit, Champalimaud Clinical Center/Champalimaud Foundation, Lisbon, Portugal.
Amber L SimpsonHepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Michael BergerHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Charles M RudinDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Diane M SimeonePerlmutter Cancer Center, New York University Langone Health, New York, NY, USA.
Maneesh JainFred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
Cyrus M GhajarPublic Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Surinder K BatraFred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
Ben Z StangerDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jack BuiDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Kristy A BrownDepartment of Medicine, Weill Cornell Medicine, New York, NY, USA.
Vinagolu K RajasekharOrthopedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
John H HealeyOrthopedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Maria de SousaChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Graduate Program in Areas of Basic and Applied Biology, Abel Salazar Biomedical Sciences Institute, University of Porto, Porto, Portugal.
Kim KramerDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sujit ShethDepartment of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Jeanine BaischDepartment of Pediatrics, Weill Cornell Medicine, New York, NY, USA; Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.
Virginia PascualDepartment of Pediatrics, Weill Cornell Medicine, New York, NY, USA; Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.
Todd E HeatonDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Pediatric Surgical Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Michael P La QuagliaDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Pediatric Surgical Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
David J PisapiaDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Robert SchwartzDivision of Gastroenterology & Hepatology, Weill Cornell Medicine, New York, NY, USA.
Haiying ZhangChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Yuan LiuThoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Arti ShuklaDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA.
Laurence BlavierDepartment of Pediatrics and Biochemistry and Molecular Medicine, University of Southern California, CA, USA.
Yves A DeClerckDepartment of Pediatrics and Biochemistry and Molecular Medicine, University of Southern California, CA, USA.
Mark LaBargeDepartment of Population Sciences, Beckman Research Institute at City of Hope, Duarte, CA, USA.
Mina J BissellLife Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Thomas C CaffreyFred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
Paul M GrandgenettFred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
Michael A HollingsworthFred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
Jacqueline BrombergDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Bruno Costa-SilvaChampalimaud Research, Champalimaud Foundation, Lisbon, Portugal.
Hector PeinadoMicroenvironment and Metastasis Laboratory, Department of Molecular Oncology, Spanish National Cancer Research Center (CNIO), Madrid, Spain.
Yibin KangDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Benjamin A GarciaDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Eileen M O'ReillyDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
David KelsenDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Tanya M TrippettDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
David R JonesThoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Irina R MateiChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
William R JarnaginHepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: jarnagiw@mskcc.org.
David LydenChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. Electronic address: dcl2001@med.cornell.edu.
Memorial Sloan Kettering Cancer Center · USCornell University · USWeill Cornell Medicine · USChildren's Cancer and Blood Foundation · USUniversity of Nebraska Medical Center · USWeizmann Institute of Science · ILNYU Langone Health · USRockefeller University · USCentro de Investigación del Cáncer · ESChampalimaud Foundation · PTPrinceton University · USUniversity of Pennsylvania · USUniversity of Southern California · USBeckman Research InstituteFred Hutch Cancer Center · USHospital Universitario Central de Asturias · ESIcahn School of Medicine at Mount Sinai · USJapan Science and Technology Agency · JPLawrence Berkeley National Laboratory · USLucile Packard Children's Hospital · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
Tissue CoreP50CA127297 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI HOLLINGSWORTH, MICHAEL A. · 2008 to 2018
$17.1M
Pancreatic Cancer Detection ConsortiumU01CA210240 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Michael A. Hollingsworth · 2017 to 2026
$12.9M
Principal ProjectU19AI144301 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Maria Virginia Pascual · 2019 to 2026
$9.9M
Systemic regulation of metastasisR35CA232093 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LYDEN, DAVID CHARLES · 2018 to 2024
$7.0M
Definition of the Microenvironment in Breast CancerR01CA064786 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI BISSELL, MINA · 1995 to 2020
$6.1M
Tumor-derived extracellular vesicles in the pre-metastatic niche.R01CA207983 · NCI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Yves A DeClerck · 2017 to 2026
$5.6M
Development and application of asymmetric-flow field-flow (AF4) technology in fractionation and characterization of exosome subpopulations and novel nanoveiscles in pancreatic cancer modelR01CA218513 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Jacob Geri, DAVID CHARLES LYDEN · 2017 to 2026
$4.3M
Role of N-Cadherin in Pancreatic Tumor MicroenvironmentU54CA163120 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BATRA, SURINDER K. · 2011 to 2015
$4.2M
Defining neoantigen immunodominance for antigen selection and biomarker discovery in human pancreatic cancer immunotherapyU01CA224175 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI BALACHANDRAN, VINOD P, LEACH, STEVEN D · 2017 to 2021
$3.1M
Characterization and Functional Analysis of Breast Cancer Secreted Exosomes in MaU01CA169538 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI BISSELL, MINA, LYDEN, DAVID CHARLES · 2012 to 2016
$2.9M
NCATS NIH HHS UL1 TR002384NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA127297NCI NIH HHS R01 CA064786NCI NIH HHS R01 CA169416NCI NIH HHS R01 CA207983NCI NIH HHS R01 CA217169NCI NIH HHS R01 CA218513NCI NIH HHS R35 CA232093NCI NIH HHS R50 CA211462NCI NIH HHS U01 CA169538NCI NIH HHS U01 CA210240NCI NIH HHS U01 CA224175NCI NIH HHS U54 CA163117NCI NIH HHS U54 CA163120NCRR NIH HHS S10 RR027699NIAID NIH HHS U19 AI144301NIOSH CDC HHS U19 OH009077
6 · The paper itself

Abstract

There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection. We investigated the proteomic profile of extracellular vesicles and particles (EVPs) in 426 human samples from tissue explants (TEs), plasma, and other bodily fluids. Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. To confirm that EVPs are ideal diagnostic tools, we analyzed proteomes of TE- (n = 151) and plasma-derived (n = 120) EVPs. Comparison of TE EVPs identified proteins (e.g., VCAN, TNC, and THBS2) that distinguish tumors from normal tissues with 90% sensitivity/94% specificity. Machine-learning classification of plasma-derived EVP cargo, including immunoglobulins, revealed 95% sensitivity/90% specificity in detecting cancer. Finally, we defined a panel of tumor-type-specific EVP proteins in TEs and plasma, which can classify tumors of unknown primary origin. Thus, EVP proteins can serve as reliable biomarkers for cancer detection and determining cancer type.

Indexed as

AnimalsBiomarkers, TumorCell LineExtracellular VesiclesHSC70 Heat-Shock ProteinsHumansMachine LearningMiceMice, Inbred C57BLMicrofilament ProteinsNeoplasmsProteomeProteomicsrap GTP-Binding ProteinsSensitivity and SpecificityTetraspanin 29Biomarkers, TumorHSC70 Heat-Shock ProteinsHSPA8 protein, humanMicrofilament ProteinsmoesinProteomeRAP1B protein, humanrap GTP-Binding ProteinsTetraspanin 29biomarkerscancercancer of unknown primary origindamage-associated molecular patternsearly cancer detectionexomeresexosomesextracellular vesicles and particlesliquid biopsyproteomics

Identifiers

PMID32795414
PMCPMC7522766
OpenAlexW3048596299

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.