ArticleNeuron2020
Brainwide Genetic Sparse Cell Labeling to Illuminate the Morphology of Neurons and Glia with Cre-Dependent MORF Mice.
Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
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- PTEN regulates starburst amacrine cell dendrite morphology during development.Development (Cambridge, England) · 2026Article
- Double-helix optical point spread function enables real-time mesoscopic 3D functional microangiography in the living mouse brain and skull.Nature communications · 2026Article
- The External Globus Pallidus is a Basal Ganglia Output Hub with Action-Specific Circuits.bioRxiv : the preprint server for biology · 2026Article
- Concordant transcriptional and morphological remodeling revealed bybioRxiv : the preprint server for biology · 2026Article
- AAV-Based Bright and Sparse Labeling of Versatile Neurons Adaptable in Cre-Dependent Genetic Backgrounds.eNeuro · 2026Article
- Fluorescent Labeling Methods for Brain Structure Research.Molecules (Basel, Switzerland) · 2026Review
- Ttc21b is required for proper proliferation of neural progenitor cells.Disease models & mechanisms · 2026Article
- Utilizing a culture system for horizontal cells to study neural circuit assembly in the developing mouse retina.Frontiers in cellular neuroscience · 2026Article
- Dendritome mapping reveals the spatial organization of striatal neuron morphology.Nature neuroscience · 2025Article
- Neural networks of the mouse visceromotor cortex.Nature · 2025Article
- Functional Neurogenomics to Dissect Disease Mechanisms Across Models.Annual review of genomics and human genetics · 2025Review
- Distinct subnetworks of the mouse anterior thalamic nuclei.Nature communications · 2025Article
- Keratinocyte-TRPV1 sensory neuron interactions in a genetically controllable mouse model of chronic neuropathic itch.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Brief sleep disruption alters synaptic structures among hippocampal and neocortical somatostatin-expressing interneurons.bioRxiv : the preprint server for biology · 2025Article
- A cell type-specific mechanism driving the rapid antidepressant effects of transcranial magnetic stimulation.bioRxiv : the preprint server for biology · 2025Article
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16 authors.
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Abstract
Cajal recognized that the elaborate shape of neurons is fundamental to their function in the brain. However, there are no simple and generalizable genetic methods to study neuronal or glial cell morphology in the mammalian brain. Here, we describe four mouse lines conferring Cre-dependent sparse cell labeling based on mononucleotide repeat frameshift (MORF) as a stochastic translational switch. Notably, the optimized MORF3 mice, with a membrane-bound multivalent immunoreporter, confer Cre-dependent sparse and bright labeling of thousands of neurons, astrocytes, or microglia in each brain, revealing their intricate morphologies. MORF3 mice are compatible with imaging in tissue-cleared thick brain sections and with immuno-EM. An analysis of 151 MORF3-labeled developing retinal horizontal cells reveals novel morphological cell clusters and axonal maturation patterns. Our study demonstrates a conceptually novel, simple, generalizable, and scalable mouse genetic solution to sparsely label and illuminate the morphology of genetically defined neurons and glia in the mammalian brain.
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