Evidence map›Paper›PMID 32795316›Full record

ArticleJournal of experimental & clinical cancer research : CR2020

Long noncoding RNA ZFPM2-AS1 acts as a miRNA sponge and promotes cell invasion through regulation of miR-139/GDF10 in hepatocellular carcinoma.

Hui He, Yawei Wang, Peng Ye, Dehui Yi, Ying Cheng, Haibo Tang, Zhi Zhu, Xun Wang, Shi Jin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of experimental & clinical cancer research : CR, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
8.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 134 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Making Sense of Antisense lncRNAs in Hepatocellular Carcinoma.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Hui HeDepartment of Laparoscopic Surgery, the First Affiliated Hospital of Dalian Medical University, Dalian, 116000, Liaoning Province, China.
Yawei WangDepartment of thoracic surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital& Institute, Shenyang, 110042, Liaoning Province, China.
Peng YeDepartment of Urological Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, 110042, Liaoning Province, China.
Dehui YiDepartment of organ transplantation& hepatobiliary surgery, the First Affiliated Hospital of China Medical University, Shenyang, 110042, Liaoning Province, China.
Ying ChengDepartment of organ transplantation& hepatobiliary surgery, the First Affiliated Hospital of China Medical University, Shenyang, 110042, Liaoning Province, China.
Haibo TangDepartment of Gastrointestinal & Hernia & Bariatric Surgery, the Third Xiangya Hospital of Central South University, Changsha, 410000, Hunan Province, China.
Zhi ZhuDepartment of Laparoscopic Surgery, the First Affiliated Hospital of Dalian Medical University, Dalian, 116000, Liaoning Province, China.
Xun WangDepartment of Laparoscopic Surgery, the First Affiliated Hospital of Dalian Medical University, Dalian, 116000, Liaoning Province, China.
Shi JinDepartment of Laparoscopic Surgery, the First Affiliated Hospital of Dalian Medical University, Dalian, 116000, Liaoning Province, China. jinshi_1969@hotmail.com.
First Affiliated Hospital of Dalian Medical University · CNChina Medical University · CNDalian Medical University · CNFirst Hospital of China Medical University · CNLiaoning Cancer Hospital & Institute · CNThird Xiangya Hospital · CN

Funding

Shenyang Science and Technology Bureau 1901210Young Scientists Fund 81702526
6 · The paper itself

Abstract

backgroundEmerging evidence has shown that dysregulated expression of long noncoding RNAs (lncRNAs) is implicated in liver hepatocellular carcinoma (HCC). However, the role and molecular mechanism of differentially expressed lncRNAs in HCC has not been fully explained.

methodsThe expression profiles of lncRNAs in HCC samples were derived from microarrays analysis or downloaded from The Cancer Genome Atlas (TCGA), and their correlation with prognosis and clinical characteristics were further analyzed. Silencing of lncRNA ZFPM2-AS1 was conducted to assess the effect of ZFPM2-AS1 in vitro. The miRcode and Target Scan databases were used to determine the lncRNA-miRNA-mRNA interactions. The biological functions were demonstrated by luciferase reporter assay, western blotting, PCR and rescue experiments.

resultsThe expression level of lncRNA ZFPM2-AS1 was significantly higher in HCC tissues than in adjacent normal tissues, and higher ZFPM2-AS1 was remarkably related to poor survival. Functionally, silencing of lncRNA ZFPM2-AS1 inhibited cell proliferation, migration, invasion and promoted cell apoptosis in vitro. Bioinformatics analysis based on the miRcode and TargetScan databases showed that lncRNA ZFPM2-AS1 regulated GDF10 expression by competitively binding to miR-139. miR-139 and downregulated GDF10 reversed cell phenotypes caused by lncRNA ZFPM2-AS1 by rescue analysis.

conclusionsZFPM2-AS1, an upregulated lncRNA in HCC, was associated with malignant tumor phenotypes and worse patient survival. ZFPM2-AS1 regulated the progression of HCC by acting as a competing endogenous RNA (ceRNA) to competitively bind to miR-139 and regulate GDF10 expression. Our study provides new insight into the posttranscriptional regulation mechanism of lncRNA ZFPM2-AS1 and suggests that ZFPM2-AS1/miR-139/GDF10 may act as a potential therapeutic target and prognostic biomarker for HCC.

Indexed as

Gene Expression Regulation, NeoplasticAnimalsApoptosisBiomarkers, TumorCarcinoma, HepatocellularCell MovementCell ProliferationDNA-Binding ProteinsFemaleGrowth Differentiation Factor 10HumansLiver NeoplasmsMaleMiceMice, Inbred BALB CMice, NudeBiomarkers, TumorDNA-Binding ProteinsGDF10 protein, humanGrowth Differentiation Factor 10MicroRNAsMIRN139 microRNA, humanRNA, AntisenseRNA, Long NoncodingTranscription FactorsZFPM2 protein, humanBioinformatics analysisLiver hepatocellular carcinomaLncRNA ZFPM2-AS1miR-139TCGA

Identifiers

PMID32795316
PMCPMC7427719
OpenAlexW3049269915

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.