Evidence map›Paper›PMID 32795292›Full record

ArticleBMC cancer2020

Log odds of positive lymph nodes is prognostically equivalent to lymph node ratio in non-metastatic colon cancer.

Ali Riaz Baqar, Simon Wilkins, Wei Wang, Karen Oliva, Paul McMurrick

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ali Riaz BaqarDepartment of Surgery, Cabrini Hospital, Cabrini Monash University, Malvern, VIC, 3144, Australia.
Simon WilkinsDepartment of Surgery, Cabrini Hospital, Cabrini Monash University, Malvern, VIC, 3144, Australia. simonwilkins@cabrini.com.au.ORCID https://orcid.org/0000-0001-7712-4114
Wei WangDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia.
Karen OlivaDepartment of Surgery, Cabrini Hospital, Cabrini Monash University, Malvern, VIC, 3144, Australia.
Paul McMurrickDepartment of Surgery, Cabrini Hospital, Cabrini Monash University, Malvern, VIC, 3144, Australia.
Cabrini Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGlobally, colorectal cancer (CRC) is the third and second leading cancer in men and women respectively with 600,000 deaths per year. Traditionally, clinicians have relied solely on nodal disease involvement, and measurements such as lymph node ratio (LNR; the ratio of metastatic/positive lymph nodes to total number of lymph nodes examined), when determining patient prognosis in CRC. The log odds of positive lymph nodes (LODDS) is a logistic transformation formula that uses pathologic lymph node data to stratify survival differences among patients within a single stage of disease. This formula allows clinicians to identify whether patients with clinically aggressive tumours fall into higher-risk groups regardless of nodal positivity and can potentially guide adjuvant treatment modalities. The aim of this study was to investigate whether LODDS in colon cancer provides better prognostication compared to LNR.

methodsA retrospective study of patients on the prospectively maintained Cabrini Monash University Department of Surgery colorectal neoplasia database, incorporating data from hospitals in Melbourne Australia, identified patients entered between January 2010 and March 2016. Association of LODDS and LNR with clinical variables were analysed. Disease-free (DFS) and overall (OS) survival were investigated with Cox regression and Kaplan-Meier survival analyses.

resultsThere were 862 treatment episodes identified in the database (402 male, 47%). The median patient age was 73 (range 22-100 years). There were 799 colonic cancers and 63 rectosigmoid cancers. The lymph node yield (LNY) was suboptimal (< 12) in 168 patients (19.5%) (p = 0.05). The 5-year OS for the different LNR groups were 86, 91 and 61% (p < 0.001) for LNR

conclusionThis study has shown for that the prognostic impact of LODDS is comparable to LNR for colon cancer patients. Accordingly, LNR is recommended for prognostication given its ease of calculation.

Indexed as

AdultAgedAged, 80 and overAustraliaChemotherapy, AdjuvantClinical Decision-MakingColectomyColonic NeoplasmsDisease-Free SurvivalFemaleFollow-Up StudiesHumansKaplan-Meier EstimateLymphatic MetastasisLymph Node RatioLymph NodesColon cancerLymph nodesPatient outcomes

Identifiers

PMID32795292
PMCPMC7427861
OpenAlexW3049272192

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.