ArticleAmerican journal of physiology. Heart and circulatory physiology2020
Endothelial deficiency of insulin-like growth factor-1 receptor reduces endothelial barrier function and promotes atherosclerosis in
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In one paragraph
Article in American journal of physiology. Heart and circulatory physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- New insights on the cardiovascular effects of IGF-1.Frontiers in endocrinology · 2023Pooled it
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- Therapeutic potential of growth hormone-releasing hormone analogues in cardiovascular and cerebrovascular diseases: mechanisms and preclinical evidence.Frontiers in pharmacology · 2026Review
- Therapeutic potential of exerkines in neurodegenerative and mental disorders: a narrative review.Frontiers in physiology · 2026Review
- Evaluating Microglial Contributions to the Neurovascular Unit in Health and Neurodegeneration Using HumanbioRxiv : the preprint server for biology · 2025Article
- Insulin use promotes pro-inflammatory changes in the transcriptome of atherosclerotic plaques in patients with diabetes mellitus.Journal of molecular and cellular cardiology plus · 2025Article
- Endothelial insulin-like growth factor-1 signalling regulates vascular barrier function and atherogenesis.Cardiovascular research · 2025Article
- Association of non-insulin-based insulin resistance indices, mean platelet volume and prostate cancer: a cross-sectional study.BMC cancer · 2025Article
- Delayed Administration of IGFBP7 Improved Bone Defect Healing via ZO-1 Dependent Vessel Stabilization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Single-Cell Transcriptomic Reveals the Involvement of Cell-Cell Junctions in the Early Development of Hypertrophic Cardiomyopathy.Journal of cellular and molecular medicine · 2025Article
- Vitamin D and exercise improve VEGF-B production and IGF-1 levels in diabetic rats: insights the role of miR-1 suppression.Scientific reports · 2025Article
- Insulin-like growth factor 1 (IGF-1)-induced changes in cardiac inducible nitric oxide synthase (iNOS) in obese rats.Frontiers in endocrinology · 2025Article
- The ion transport, GPCR, and RTK toolkit expression in the human cerebrovascular endothelial cell line, hCMEC/D3: an Omics perspective.Frontiers in physiology · 2025Article
- Plasma exosomes from patients with coronary artery disease promote atherosclerosis via impairing vascular endothelial junctions.Scientific reports · 2024Article
- The involvement of Akt, mTOR, and S6K in the in vivo effect of IGF-1 on the regulation of rat cardiac NaMolecular biology reports · 2024Article
- Heterogeneity of endothelial VE-PTP downstream polarization, Tie2 activation, junctional claudin-5, and permeability in the aorta and vena cava.Cell and tissue research · 2024Article
- Hallmarks of cardiovascular ageing.Nature reviews. Cardiology · 2023Review
- The role of the endothelium in severe acute respiratory syndrome coronavirus 2 infection and pathogenesis.Current opinion in physiology · 2023Review
- The pulmonary vasculature in lethal COVID-19 and idiopathic pulmonary fibrosis at single-cell resolution.Cardiovascular research · 2023Article
- Insulin-like growth factor 1 reduces coronary atherosclerosis in pigs with familial hypercholesterolemia.JCI insight · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 1 country.
Yusuke HigashiDepartment of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.
Sergiy SukhanovDepartment of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.
Shaw-Yung ShaiDepartment of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.
Svitlana DanchukDepartment of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.
Patricia SnarskiDepartment of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.ORCID 0000-0002-2470-7655
Zhaohui LiDepartment of Radiology, University of Missouri School of Medicine, Columbia, Missouri.
Xuwei HouDepartment of Medicine, University of Missouri School of Medicine, Columbia, Missouri.
Milton H HamblinDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
T Cooper WoodsDepartment of Physiology, Tulane University School of Medicine, New Orleans, Louisiana.
Meifang WangDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri.
Derek WangDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri.
Hong YuDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri.
Ronald J KorthuisDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri.
Tadashi YoshidaDepartment of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.
Patrice DelafontaineDepartment of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.
Tulane University · USUniversity of Missouri · US
Funding
Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Leigh Lamonica · 2012 to 2026
$69.1MInsulin-Like Growth Factor-1and AtherosclerosisR01HL070241 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI PATRICE DELAFONTAINE · 2003 to 2026
$10.1MPain Management and Functional Recovery in Older AdultsR01AG022108 · NIA · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI MORRISON, R. SEAN · 2003 to 2006
$1.7MDaily Moderate Ethanol Ingestion Attenuates Postischemic Microvascular DysfunctioR01AA022108 · NIAAA · UNIVERSITY OF MISSOURI-COLUMBIA · PI KORTHUIS, RONALD JOHN · 2015 to 2019
$1.7MGAPDH, DNA Repair and AtherosclerosisR01HL142796 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI SUKHANOV, SERGIY · 2019 to 2022
$1.5MRole of VSMC-Derived Exosomes in the Cardiovascular Complications of DiabetesR01HL127092 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI WOODS, THOMAS COOPER · 2016 to 2019
$1.5MHHS | NIH | National Heart, Lung, and Blood Institute (NHBLI) R01-HL070241HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI) R01-HL127092HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI) R01-HL142796HHS | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAA) R01-AA022108NHLBI NIH HHS R01 HL070241NHLBI NIH HHS R01 HL127092NHLBI NIH HHS R01 HL142796NIAAA NIH HHS R01 AA022108NIGMS NIH HHS U54 GM104940
Abstract
Insulin-like growth factor-1 (IGF-1) decreases atherosclerosis in apolipoprotein E (
Indexed as
Capillary PermeabilityAnimalsAntigens, CDAortic DiseasesAtherosclerosisCadherin 5CadherinsDisease Models, AnimalDisease ProgressionEndothelial CellsHumansMice, Inbred C57BLMice, Knockout, ApoEPlaque, AtheroscleroticPlatelet Endothelial Cell Adhesion Molecule-1Receptor, IGF Type 1Antigens, CDCadherin 5CadherinsIGF1R protein, humanIgf1r protein, mousePECAM1 protein, humanPlatelet Endothelial Cell Adhesion Molecule-1Receptor, IGF Type 1Tight Junction ProteinsatherosclerosisendotheliumIGFinsulin likevascular permeability
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.