Evidence map›Paper›PMID 32794627›Full record

ReviewInternational journal of experimental pathology2020

The cellular origins of cancer with particular reference to the gastrointestinal tract.

Malcolm R Alison

Open access · greenAbstract readReview
In one paragraph

Review in International journal of experimental pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Mitochondrial function and gastrointestinal diseases.Nature reviews. Gastroenterology & hepatology · 2024
    Review
  7. Review
  8. Review
  9. Article
  10. A framework for fibrolamellar carcinoma research and clinical trials.Nature reviews. Gastroenterology & hepatology · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Malcolm R AlisonCentre for Tumour Biology, Barts Cancer Institute, Charterhouse Square, Barts and The London School of Medicine and Dentistry, London, UK.ORCID 0000-0002-7348-3387
Queen Mary University of London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stem cells or their closely related committed progenitor cells are the likely founder cells of most neoplasms. In the continually renewing and hierarchically organized epithelia of the oesophagus, stomach and intestine, homeostatic stem cells are located at the beginning of the cell flux, in the basal layer of the oesophagus, the isthmic region of gastric oxyntic glands and at the bottom of gastric pyloric-antral glands and colonic crypts. The introduction of mutant oncogenes such as Kras

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsBile Duct NeoplasmsCarcinogenesisCarcinoma, HepatocellularCarcinoma, Pancreatic DuctalCholangiocarcinomaDisease Models, AnimalGastrointestinal TractHumansLiver NeoplasmsMetaplasiaMiceMutationNeoplastic Stem CellsPancreasBasic Helix-Loop-Helix ProteinsBhlha15 protein, mouseHras protein, mouseLgr5 protein, mouseProto-Oncogene Proteins p21(ras)Receptors, G-Protein-CoupledTrp53 protein, mouseTumor Suppressor Protein p53clonalityCre recombinasefield cancerizationLgr5metaplasiastem cells

Identifiers

PMID32794627
PMCPMC7495846
OpenAlexW3049209714

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.