Evidence map›Paper›PMID 32794424›Full record

ArticleRNA biology2021

Pan-RNA editing analysis of the bovine genome.

Wentao Cai, Lijun Shi, Mingyue Cao, Dan Shen, Junya Li, Shengli Zhang, Jiuzhou Song

Open access · bronzeAbstract read
In one paragraph

Article in RNA biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Wentao CaiInstitute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China.ORCID 0000-0002-5639-1755
Lijun ShiInstitute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China.
Mingyue CaoKey Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture & National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Dan ShenKey Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture & National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Junya LiInstitute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China.
Shengli ZhangKey Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture & National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Jiuzhou SongDepartment of Animal and Avian Science, University of Maryland, College Park, USA.
China Agricultural University · CNChinese Academy of Agricultural Sciences · CNUniversity of Maryland, College Park · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RNA editing is an essential process for modifying nucleotides at specific RNA sites during post-transcription in many species. However, its genomic landscape and characters have not been systematically explored in the bovine genome. In the present study, we characterized global RNA editing profiles from 50 samples of cattle and revealed a range of RNA editing profiles in different tissues. Most editing sites were significantly enriched in specific BovB-derived SINEs, especially the dispersed Bov-tAs, which likely forms dsRNA structures similar to the primate-specific Alu elements. Interestingly, ADARB1 (ADAR2) was observed to be predominant in determining global editing in the bovine genome. Common RNA editing sites among similar tissues were associated with tissue-specific biological functions. Taken together, the wide distribution of RNA editing sites and their tissue-specific characters implied the bovine RNA editome should be further explored.

Indexed as

GenomeGenomicsRNA EditingAdenosine DeaminaseAnimalsCattleConserved SequenceEvolution, MolecularGene Expression RegulationHumansMiceMultigene FamilyOrgan SpecificityRepetitive Sequences, Nucleic AcidShort Interspersed Nucleotide ElementsSpecies SpecificityAdenosine DeaminaseADARA-to-G edited clustersBovB-derived SINEsbovinerepetitive elementsRNA editing

Identifiers

PMID32794424
PMCPMC7951967
OpenAlexW3049202833

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.