Evidence map›Paper›PMID 32794343›Full record

ArticleAnnals of clinical and translational neurology2020

Dual tasking impairments are associated with striatal pathology in Huntington's disease.

Johnny Lo, Alvaro Reyes, Timothy S Pulverenti, Timothy J Rankin, Danielle M Bartlett, Pauline Zaenker, Grant Rowe, Kirk Feindel, Govinda Poudel, Nellie Georgiou-Karistianis and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Accidental Falls in Patients with Hyperkinetic Movement Disorders: A Systematic Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2022
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Tracking Huntington's Disease Progression Using Motor, Functional, Cognitive, and Imaging Markers.Movement disorders : official journal of the Movement Disorder Society · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Johnny LoSchool of Science, Edith Cowan University, Joondalup, Western Australia, Australia.
Alvaro ReyesFacultad de Ciencias de la Rehabilitacion, Universidad Andres Bello, Viña del Mar, Chile.ORCID 0000-0001-7703-2893
Timothy S PulverentiDepartment of Physical Therapy, College of Staten Island, The City University of New York, Staten Island, NY.
Timothy J RankinSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Danielle M BartlettSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.ORCID 0000-0002-6096-3760
Pauline ZaenkerSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Grant RoweSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Kirk FeindelSchool of Biomedical Sciences, University of Western Australia, Perth, Western Australia, Australia.
Govinda PoudelMary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.
Nellie Georgiou-KaristianisSchool of Psychological Sciences and the Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia.
Mel R ZimanSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Travis M CruickshankSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Edith Cowan University · AUAustralian Catholic University · AUCollege of Staten Island · USMonash University · AUThe University of Western Australia · AUUniversidad Andrés Bello · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent findings suggest that individuals with Huntington's disease (HD) have an impaired capacity to execute cognitive and motor tasks simultaneously, or dual task, which gradually worsens as the disease advances. The onset and neuropathological changes mediating impairments in dual tasking in individuals with HD are unclear. The reliability of dual tasking assessments for individuals with HD is also unclear.

objectivesTo evaluate differences in dual tasking performance between individuals with HD (presymptomatic and prodromal) and matched controls, to investigate associations between striatal volume and dual tasking performance, and to determine the reliability of dual tasking assessments.

methodsTwenty individuals with HD (10 presymptomatic and 10 prodromal) and 20 healthy controls were recruited for the study. Individuals undertook four single and dual task assessments, comprising motor (postural stability or force steadiness) and cognitive (simple or complex mental arithmetic) components, with single and dual tasks performed three times each. Participants also undertook a magnetic resonance imaging assessment.

resultsCompared to healthy controls, individuals with presymptomatic and prodromal HD displayed significant deficits in dual tasking, particularly cognitive task performance when concurrently undertaking motor tasks (P < 0.05). The observed deficits in dual tasking were associated with reduced volume in caudate and putamen structures (P < 0.05),however, not with clinical measures of disease burden. An analysis of the reliability of dual tasking assessments revealed moderate to high test-retest reliability [ICC: 0.61-0.99] for individuals with presymptomatic and prodromal HD and healthy controls.

conclusionsIndividuals with presymptomatic and prodromal HD have significant deficits in dual tasking that are associated with striatal degeneration. Findings also indicate that dual tasking assessments are reliable in individuals presymptomatic and prodromal HD and healthy controls.

Indexed as

AdultCognitive DysfunctionExecutive FunctionHumansHuntington DiseaseMagnetic Resonance ImagingMaleMiddle AgedNeostriatumPostural BalanceProdromal SymptomsPsychomotor Performance

Identifiers

PMID32794343
PMCPMC7480913
OpenAlexW3049077608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.