Evidence map›Paper›PMID 32794340›Full record

ArticleCancer medicine2020

Long noncoding RNA HCG11 inhibited growth and invasion in cervical cancer by sponging miR-942-5p and targeting GFI1.

Yan Zhang, Jun Zhang, Lin Mao, Xing Li

RetractedOpen access · goldAbstract readRetracted Publication
In one paragraph

Article in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yan ZhangDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, China.ORCID 0000-0001-7798-531X
Jun ZhangDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, China.
Lin MaoDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, China.
Xing LiDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, China.
Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long noncoding RNAs (lncRNAs) act as essential regulators in cancer tumorigenesis. Our study aimed to explore the underlying mechanism of lncRNA human leukocyte antigen complex group 11 (HCG11) in cervical cancer (CC) progression. Long noncoding RNA HCG11 was downregulated in CC. Functional assays demonstrated that lncRNA HCG11 inhibited CC cell proliferation and invasion. Then, we confirmed that lncRNA HCG11 could directly bind to miR-942-5p. Moreover, inhibition of miR-942-5p suppressed the growth and invasion of CC cells, and growth factor-independent transcription repressor 1 (GFI1) gene was the target gene of miR-942-5p. Long noncoding RNA HCG11 increased the expression of GFI1 and suppressed cell proliferation and invasion by acting as a miR-942-5p sponge. Finally, the overexpression of lncRNA HCG11 suppressed the proliferation and metastasis of CC cells in vivo.

Indexed as

Cell MovementCell ProliferationAnimalsDNA-Binding ProteinsFemaleGene Expression Regulation, NeoplasticHeLa CellsHumansMice, NudeMicroRNAsNeoplasm InvasivenessRNA, Long NoncodingSignal TransductionTranscription FactorsTumor BurdenUterine Cervical NeoplasmsDNA-Binding ProteinsGFI1 protein, humanlong noncoding RNA HCG11, humanMicroRNAsMIRN942 microRNA, humanRNA, Long NoncodingTranscription Factorscervical cancergrowthinvasionlncRNA HCG11miR-942-5p

Identifiers

PMID32794340
PMCPMC7541137
OpenAlexW3048898073

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.