ArticleProceedings of the National Academy of Sciences of the United States of America1988
Immunological significance of Mycobacterium leprae cell walls.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 66 citations in OpenAlex.
- Quality control of BCG vaccine by WHO: a review of factors that may influence vaccine effectiveness and safety.Bulletin of the World Health Organization · 1990Trial
- Multi-omic detection ofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
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- Recombinant BCG Expressing HTI Prime and Recombinant ChAdOx1 Boost Is Safe and Elicits HIV-1-Specific T-Cell Responses in BALB/c Mice.Vaccines · 2019Article
- MTBVAC-Based TB-HIV Vaccine Is Safe, Elicits HIV-T Cell Responses, and Protects againstMolecular therapy. Methods & clinical development · 2019Article
- Priming With Recombinant BCG Expressing Novel HIV-1 Conserved Mosaic Immunogens and Boosting With Recombinant ChAdOx1 Is Safe, Stable, and Elicits HIV-1-Specific T-Cell Responses in BALB/c Mice.Frontiers in immunology · 2019Article
- The challenge of producing skin test antigens with minimal resources suitable for human application against a neglected tropical disease; leprosy.PLoS neglected tropical diseases · 2014Article
- Identification of mimotopes of Mycobacterium leprae as potential diagnostic reagents.BMC infectious diseases · 2013Article
- Persistent inactivation of macrophage cyclooxygenase-2 in mycobacterial pulmonary inflammation.American journal of respiratory cell and molecular biology · 2009Article
- Target organ localization of memory CD4(+) T cells in patients with chronic beryllium disease.The Journal of clinical investigation · 2002Article
- Characterisation of Eubacterium cell wall: peptidoglycan structure determines arthritogenicity.Annals of the rheumatic diseases · 2001Article
- Identification of phosphatidylinositol mannoside as a mycobacterial adhesin mediating both direct and opsonic binding to nonphagocytic mammalian cells.Infection and immunity · 1997Article
- An immunodominant 30-kDa antigen of a candidate anti-leprosy vaccine, Mycobacterium w, shares T and B cell determinants with M. leprae and M. tuberculosis.Medical microbiology and immunology · 1993Article
- Identification and characterization of epitopes shared between the mycobacterial 65-kilodalton heat shock protein and the actively secreted antigen 85 complex: their in situ expression on the cell wall surface of Mycobacterium leprae.Infection and immunity · 1992Article
- A major T cell antigen of Mycobacterium leprae is a 10-kD heat-shock cognate protein.The Journal of experimental medicine · 1992Article
- Protective efficacy of different cell-wall fractions of Mycobacterium tuberculosis.Folia microbiologica · 1992Article
- Review
- Repertoires of antibodies to culture filtrate antigens in different mouse strains infected with Mycobacterium bovis BCG.Infection and immunity · 1990Article
- Identification of an immunostimulating protein from Mycobacterium leprae.Infection and immunity · 1990Article
- Peptidoglycan-associated polypeptides of Mycobacterium tuberculosis.Journal of bacteriology · 1990Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Cell walls of Mycobacterium leprae, prepared by differential solvent extraction, were shown to contain arabinogalactan, mycolates, and peptidoglycan. In addition, amino acid analysis revealed the unexpected presence of large amounts of protein that retained potent immunological reactivity. Purified cell walls stimulated proliferation of T cells from tuberculoid, but not from lepromatous leprosy, patients and elicited delayed-type hypersensitivity skin reactions in guinea pigs and patients sensitized to M. leprae. Analysis of the precursor frequency of antigen-reactive human peripheral T cells revealed that as many cells (approximately equal to 1/6000) proliferate to antigen contained in cell walls as to intact M. leprae. Sequential removal of mycolates and arabinogalactan resulted in a large peptidoglycan-protein complex that retained all the immunological activity. This immunological reactivity and the inherent protein were destroyed by proteolysis. Thus, cell wall protein is a major contributor to cell-mediated immune reactivity to this pathogenic mycobacterium.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.