Evidence map›Paper›PMID 32794189›Full record

ArticleImmunology2020

The cytotoxic molecule granulysin is capable of inducing either chemotaxis or fugetaxis in dendritic cells depending on maturation: a role for Vδ2

Emma L Sparrow, Daniel W Fowler, Joe Fenn, Jonathan Caron, John Copier, Angus G Dalgleish, Mark D Bodman-Smith

Open access · hybridAbstract read
In one paragraph

Article in Immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Emma L SparrowInfection and Immunity Research Institute, St. George's University of London SW17 0RE, London, UK.ORCID 0000-0003-2987-0571
Daniel W FowlerInfection and Immunity Research Institute, St. George's University of London SW17 0RE, London, UK.
Joe FennInfection and Immunity Research Institute, St. George's University of London SW17 0RE, London, UK.
Jonathan CaronInfection and Immunity Research Institute, St. George's University of London SW17 0RE, London, UK.
John CopierInfection and Immunity Research Institute, St. George's University of London SW17 0RE, London, UK.
Angus G DalgleishInfection and Immunity Research Institute, St. George's University of London SW17 0RE, London, UK.
Mark D Bodman-SmithInfection and Immunity Research Institute, St. George's University of London SW17 0RE, London, UK.
St George's, University of London · GB

Funding

Institute for Cancer Vaccines and Immunotherapy
6 · The paper itself

Abstract

Release of granulysin by γδ T cells contributes to tumour cell killing. A cytolytic 9000 MW isoform of granulysin kills tumour cells directly, whereas a 15 000 MW precursor has been hypothesized to cause both the maturation and migration of dendritic cell (DC) populations. Recruiting DC to a tumour is beneficial as these cells initiate adaptive immune responses, which contribute to the eradication of malignancies. In this study, Vδ2

Indexed as

Antigens, Differentiation, T-LymphocyteCell DifferentiationCell MovementCells, CulturedChemotaxisCoculture TechniquesCytotoxicity, ImmunologicDendritic CellsHumansLymphocyte ActivationLymphoma, B-CellMycobacterium bovisReceptors, Antigen, T-Cell, gamma-deltaT-LymphocytesZoledronic AcidAntigens, Differentiation, T-LymphocyteGNLY protein, humanReceptors, Antigen, T-Cell, gamma-deltaT-cell receptor Vdelta2, humanZoledronic Acidchemotaxisdendritic cellsgranulysinγδ T cells

Identifiers

PMID32794189
PMCPMC7576882
OpenAlexW3049251972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.