Evidence map›Paper›PMID 32794054›Full record

ArticlePflugers Archiv : European journal of physiology2020

Concurrent increases in post-pacing action potential duration and contractility predict occurrence of ventricular arrhythmia.

Chih-Min Liu, Feng-Zhi Lin, Yao-Chang Chen, Yung-Kuo Lin, Yen-Yu Lu, Cheng-I Wu, Satoshi Higa, Shih-Ann Chen, Yi-Jen Chen

Abstract read
PubMed Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Disease severity, arrhythmogenesis, and fibrosis are related to longer action potentials in tetralogy of Fallot.Clinical research in cardiology : official journal of the German Cardiac Society · 2024
    Article
  2. Review
  3. Inhibition of Voltage-Gated NaInternational journal of molecular sciences · 2023
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Chih-Min LiuHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Feng-Zhi LinGraduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.
Yao-Chang ChenDepartment of Biomedical Engineering, National Defense Medical Center, Taipei, Taiwan.
Yung-Kuo LinDivision of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, 111 Hsin-Lung Road, Sec. 3, Taipei, Taiwan.
Yen-Yu LuDivision of Cardiology, Sijhih Cathay General Hospital, New Taipei City, Taiwan.
Cheng-I WuHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Satoshi HigaCardiac Electrophysiology and Pacing Laboratory, Division of Cardiovascular Medicine, Makiminato Central Hospital, Okinawa, Japan.
Shih-Ann ChenHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Yi-Jen ChenDivision of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, 111 Hsin-Lung Road, Sec. 3, Taipei, Taiwan. yjchen@tmu.edu.tw.
National Defense Medical Center · TWCathay General Hospital · TWNational Yang Ming Chiao Tung University · TWNational Yang Ming University Hospital · TWTaipei Medical University · TWTaipei Veterans General Hospital · TWTomishiro Central Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excitation-contraction coupling from the integration of action potential duration (APD) and muscle contractility plays an important role in arrhythmogenesis. We aimed to determine whether distinctive excitation-contraction coupling contributes to the genesis of ventricular tachycardias (VTs). Action potential (AP) and mechanical activity were simultaneously recorded under electrical pacing (cycle lengths from 1000 to 100 ms) in the tissue model created from isolated rabbit right ventricular outflow tracts treated with NS 5806 (10 μM, transient outward potassium current enhancer), pinacidil (2 μM, ATP-sensitive potassium channel opener), and pilsicainide (5 μM, sodium channel blocker). There were 15 (9.9%) inducible VT episodes (group 1) and 136 (90.1%) non-inducible VT episodes (group 2) in our tissue model. Group 1 had greater post-pacing increases of the first occurrence of AP at 90% repolarization (ΔAPD

Indexed as

Action PotentialsMyocardial ContractionAnimalsAnti-Arrhythmia AgentsHeartHeart RateLidocaineMalePhenylurea CompoundsPinacidilRabbitsSodium Channel BlockersTachycardia, VentricularTetrazoles1-(3,5-bis-trifluoromethylphenyl)-3-(2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl)ureaAnti-Arrhythmia AgentsLidocainePhenylurea CompoundspilsicainidePinacidilSodium Channel BlockersTetrazolesAction potential depolarizationContractilityNa+–Ca2+ exchanger inhibitorVentricular arrhythmias

Identifiers

PMID32794054
OpenAlexW3049728148

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.