Evidence map›Paper›PMID 32794008›Full record

ArticleAnalytical and bioanalytical chemistry2020

Targeted LC-ESI-MS

Marko Mank, Hans Hauner, Albert J R Heck, Bernd Stahl

Abstract read
In one paragraph

Article in Analytical and bioanalytical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Marko MankDanone Nutricia Research, Uppsalalaan 12, 3584 CT, Utrecht, The Netherlands. marko.mank@danone.com.ORCID http://orcid.org/0000-0001-7695-3906
Hans HaunerElse Kröner-Fresenius Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675, Munich, Germany.
Albert J R HeckBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Padualaan 8, 3584 CH, Utrecht, The Netherlands.
Bernd StahlDanone Nutricia Research, Uppsalalaan 12, 3584 CT, Utrecht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many molecular components in human milk (HM), such as human milk oligosaccharides (HMOs), assist in the healthy development of infants. It has been hypothesized that the functional benefits of HM may be highly dependent on the abundance and individual fine structures of contained HMOs and that distinctive HM groups can be defined by their HMO profiles. However, the structural diversity and abundances of individual HMOs may also vary between milk donors and at different stages of lactations. Improvements in efficiency and selectivity of quantitative HMO analysis are essential to further expand our understanding about the impact of HMO variations on healthy early life development. Hence, we applied here a targeted, highly selective, and semi-quantitative LC-ESI-MS

Indexed as

Postpartum PeriodBreast FeedingChromatography, LiquidFemaleHumansInfantLewis Blood Group AntigensMilk, HumanOligosaccharidesSpectrometry, Mass, Electrospray IonizationLewis Blood Group AntigensOligosaccharides3-FL6′-SLHuman milk groups/milktypingHuman milk oligosaccharides (HMOs)Principal component analysis (PCA)Secretor (Se) and Lewis (Le) gene–dependent or Secretor (Se) and Lewis (Le) gene–independent HMOsStages of lactationTargeted LC-MS2

Identifiers

PMID32794008
PMCPMC7496073

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.