Evidence map›Paper›PMID 32793651›Full record

ArticleFrontiers in veterinary science2020

Genetic Diversity of Porcine Epidemic Diarrhea Virus With a Naturally Occurring Truncated ORF3 Gene Found in Guangxi, China.

Ying Lu, Xueli Su, Chen Du, Liyuan Mo, Purui Ke, Ruomu Wang, Lian Zhong, Cui Yang, Ying Chen, Zuzhang Wei and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in veterinary science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Ying LuLaboratory of Animal Infectious Disease and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China.
Xueli SuLaboratory of Animal Infectious Disease and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China.
Chen DuLaboratory of Animal Infectious Disease and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China.
Liyuan MoLaboratory of Animal Infectious Disease and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China.
Purui KeLaboratory of Animal Infectious Disease and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China.
Ruomu WangLaboratory of Animal Infectious Disease and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China.
Lian ZhongLaboratory of Animal Infectious Disease and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China.
Cui YangLaboratory of Poultry, Guangxi Institute of Animal Science, Nanning, China.
Ying ChenLaboratory of Animal Infectious Disease and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China.
Zuzhang WeiLaboratory of Animal Infectious Disease and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China.
Weijian HuangLaboratory of Animal Infectious Disease and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China.
Yuying LiaoLaboratory of Poultry, Guangxi Institute of Animal Science, Nanning, China.
Kang OuyangLaboratory of Animal Infectious Disease and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China.
Guangxi University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porcine epidemic diarrhea virus (PEDV) is one of the major enteric pathogens, causing severe enteric disease, resulting in enormous economic losses. The ORF3 gene encodes an accessory protein which is related to the infectivity and virulence of PEDV. In this study, 33 PEDV positive field samples were collected from Guangxi, from 2017 to 2019, and the genetic diversity of ORF3 was investigated. Thirty-eight strains of ORF3 were obtained, and these were composed of five strains of ORF3 named Guangxi naturally truncated strains that were 293 bp in length, with continuous deletions from 172 to 554 bp. The Guangxi naturally truncated strains encoded a truncated protein of 89 amino acids, which had clustered into a new group referred to as Group 3, and these might be involved in the variations of virulence. Three genotypes (G1-1 subgroup, G1-3 subgroup, and Group 3) existed simultaneously in Guangxi based on the genetic and evolutionary analysis of the ORF3 gene. The sequence information in the current study will hopefully facilitate the establishment of a diagnostic method that can differentiate the PEDV field stains. Continued surveillance will be useful for monitoring PEDV transmission. Differentiation of the ORF3 genes in PEDV field strains can help us to choose an appropriate PEDV vaccine candidate in the future and prevent outbreaks of PED more effectively.

Indexed as

genetic diversitynaturally truncated geneORF3PEDVpigs

Identifiers

PMID32793651
PMCPMC7393948
OpenAlexW3044169289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.