ArticleFrontiers in cell and developmental biology2020
Alterations of the Hippocampal Neurogenic Niche in a Mouse Model of Dravet Syndrome.
Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 22 citations in OpenAlex.
- Astrocytes in Genetic Epilepsies: Supporting Actor or Key Player?Journal of neuroscience research · 2026Review
- Long-lasting remodeling of astrocytes in an Scna1Epilepsia · 2026Article
- Article
- Investigation in blood-brain barrier integrity and susceptibility to immune cell penetration in a mouse model of Dravet syndrome.Brain, behavior, & immunity - health · 2025Article
- Picrotoxin-Induced Epileptogenic Hippocampal Organotypic Slice Cultures (hOTCs).Methods in molecular biology (Clifton, N.J.) · 2025Article
- Blockage of STAT3 during epileptogenesis prevents GABAergic loss and imprinting of the epileptic state.Brain : a journal of neurology · 2023Article
- Migratory Response of Cells in Neurogenic Niches to Neuronal Death: The Onset of Harmonic Repair?International journal of molecular sciences · 2023Review
- Retinal Tissue Shows Glial Changes in a Dravet Syndrome Knock-in Mouse Model.International journal of molecular sciences · 2023Article
- The differential response to neuronal hyperexcitation and neuroinflammation of the hippocampal neurogenic niche.Frontiers in neuroscience · 2023Article
- Does the plasticity of neural stem cells and neurogenesis make them biosensors of disease and damage?Frontiers in neuroscience · 2022Article
- Transfer ofMolecular therapy. Nucleic acids · 2021Article
- Multipronged Attack of Stem Cell Therapy in Treating the Neurological and Neuropsychiatric Symptoms of Epilepsy.Frontiers in pharmacology · 2021Review
- Neuropathological Characterization of a Dravet Syndrome Knock-In Mouse Model Useful for Investigating Cannabinoid Treatments.Frontiers in molecular neuroscience · 2020Article
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Authors and funding
5 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Hippocampal neurogenesis, the process by which neural stem cells (NSCs) continuously generate new neurons in the dentate gyrus (DG) of most mammals including humans, is chiefly regulated by neuronal activity. Thus, severe alterations have been found in samples from epilepsy patients and in the hippocampal neurogenic niche in mouse models of epilepsy. Reactive-like and gliogenic NSCs plus aberrant newborn neurons with altered migration, morphology, and functional properties are induced by seizures in experimental models of temporal lobe epilepsy. Hippocampal neurogenesis participates in memory and learning and in the control of anxiety and stress. It has been therefore hypothesized that part of the cognitive symptoms associated with epilepsy could be promoted by impaired hippocampal neurogenesis. We here analyze for the first time the alterations of the neurogenic niche in a novel mouse model of Dravet syndrome (DS), a genetic encephalopathy with severe epilepsy in infancy and multiple neurological comorbidities. Scn1a
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