Evidence map›Paper›PMID 32793592›Full record

ArticleFrontiers in cell and developmental biology2020

DNA Methyltransferase 1 (DNMT1) Function Is Implicated in the Age-Related Loss of Cortical Interneurons.

Anne Hahn, Daniel Pensold, Cathrin Bayer, Jessica Tittelmeier, Lourdes González-Bermúdez, Lisa Marx-Blümel, Jenice Linde, Jonas Groß, Gabriela Salinas-Riester, Thomas Lingner and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

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  6. Neuronal activity-dependent gene dysregulation inAmerican journal of physiology. Cell physiology · 2025
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  14. Role of DNMTs in the Brain.Advances in experimental medicine and biology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Anne HahnDepartment of Functional Epigenetics, Institute of Human Genetics, University Hospital Jena, Jena, Germany.
Daniel PensoldDepartment of Functional Epigenetics, Institute of Human Genetics, University Hospital Jena, Jena, Germany.
Cathrin BayerDepartment of Functional Epigenetics, Institute of Human Genetics, University Hospital Jena, Jena, Germany.
Jessica TittelmeierDepartment of Functional Epigenetics, Institute of Human Genetics, University Hospital Jena, Jena, Germany.
Lourdes González-BermúdezDepartment of Functional Epigenetics, Institute of Human Genetics, University Hospital Jena, Jena, Germany.
Lisa Marx-BlümelDepartment of Functional Epigenetics, Institute of Human Genetics, University Hospital Jena, Jena, Germany.
Jenice LindeDepartment of Functional Epigenetics in the Animal Model, Institute of Biology II, RWTH Aachen University, Aachen, Germany.
Jonas GroßDepartment of Functional Epigenetics, Institute of Human Genetics, University Hospital Jena, Jena, Germany.
Gabriela Salinas-RiesterTranscriptome and Genome Analysis Laboratory (TAL), Department of Developmental Biochemistry, University of Göttingen, Göttingen, Germany.
Thomas LingnerTranscriptome and Genome Analysis Laboratory (TAL), Department of Developmental Biochemistry, University of Göttingen, Göttingen, Germany.
Julia von MaltzahnLeibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany.
Marc SpehrResearch Training Group 2416 MultiSenses - MultiScales, RWTH Aachen University, Aachen, Germany.
Tomas PielerCentre for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), Department of Developmental Biochemistry, University of Göttingen, Göttingen, Germany.
Anja UrbachInstitute of Neurology, University Hospital Jena, Jena, Germany.
Geraldine Zimmer-BenschDepartment of Functional Epigenetics, Institute of Human Genetics, University Hospital Jena, Jena, Germany.
Jena University Hospital · DERWTH Aachen University · DEUniversity of Göttingen · DELeibniz Institute on Aging - Fritz Lipmann Institute (FLI) · DENanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 — DFG Research Center 103 · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increased life expectancy in modern society comes at the cost of age-associated disabilities and diseases. Aged brains not only show reduced excitability and plasticity, but also a decline in inhibition. Age-associated defects in inhibitory circuits likely contribute to cognitive decline and age-related disorders. Molecular mechanisms that exert epigenetic control of gene expression contribute to age-associated neuronal impairments. Both DNA methylation, mediated by DNA methyltransferases (DNMTs), and histone modifications maintain neuronal function throughout lifespan. Here we provide evidence that DNMT1 function is implicated in the age-related loss of cortical inhibitory interneurons.

Indexed as

agingcerebral cortexDNA methylationGABAinhibitory interneuronsproteostasissynapsetranscriptional control

Identifiers

PMID32793592
PMCPMC7387673
OpenAlexW3044325971

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.