Evidence map›Paper›PMID 32793567›Full record

ArticleFrontiers in bioengineering and biotechnology2020

A Theoretical and Experimental Study to Optimize Cell Differentiation in a Novel Intestinal Chip.

Nicky Langerak, Haysam M M Ahmed, Yang Li, Igor R Middel, Hossein Eslami Amirabadi, Jos Malda, Rosalinde Masereeuw, René van Roij

Abstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. In Vitro Models for Investigating Intestinal Host-Pathogen Interactions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. The Progress of Intestinal Epithelial Models from Cell Lines to Gut-On-Chip.International journal of molecular sciences · 2021
    Review
  16. Article
  17. Oncoimmunology Meets Organs-on-Chip.Frontiers in molecular biosciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicky LangerakInstitute for Theoretical Physics, Utrecht University, Utrecht, Netherlands.
Haysam M M AhmedDivision of Pharmacology, Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands.
Yang LiUtrecht Biofabrication Facility, University Medical Center Utrecht, Utrecht, Netherlands.
Igor R MiddelDivision of Pharmacology, Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands.
Hossein Eslami AmirabadiDivision of Pharmacology, Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands.
Jos MaldaUtrecht Biofabrication Facility, University Medical Center Utrecht, Utrecht, Netherlands.
Rosalinde MasereeuwDivision of Pharmacology, Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands.
René van RoijInstitute for Theoretical Physics, Utrecht University, Utrecht, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microphysiological systems have potential as test systems in studying the intestinal barrier, in which shear stress is critical for the differentiation of Caco-2 cells into enterocytes. The most commonly used

Indexed as

3D printingcell differentiationgut-on-chipnumerical computationshear stress

Identifiers

PMID32793567
PMCPMC7393935

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.