Evidence map›Paper›PMID 32793515›Full record

ArticleFrontiers in cellular and infection microbiology2020

Alterations of Gut Microbiome in Tibetan Patients With Coronary Heart Disease.

Fengyun Liu, Chao Fan, Liangzhi Zhang, Yuan Li, Haiwen Hou, Yan Ma, Jinhua Fan, Yueqin Tan, Tianyi Wu, Shangang Jia and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Fengyun LiuNational Key Laboratory of High Altitude Medicine, Qinghai High Altitude Medical Research Institute, Xining, China.
Chao FanKey Laboratory of Adaptation and Evolution of Plateau Biota, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, China.
Liangzhi ZhangKey Laboratory of Adaptation and Evolution of Plateau Biota, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, China.
Yuan LiNational Key Laboratory of High Altitude Medicine, Qinghai High Altitude Medical Research Institute, Xining, China.
Haiwen HouNational Key Laboratory of High Altitude Medicine, Qinghai High Altitude Medical Research Institute, Xining, China.
Yan MaNational Key Laboratory of High Altitude Medicine, Qinghai High Altitude Medical Research Institute, Xining, China.
Jinhua FanNational Key Laboratory of High Altitude Medicine, Qinghai High Altitude Medical Research Institute, Xining, China.
Yueqin TanNational Key Laboratory of High Altitude Medicine, Qinghai High Altitude Medical Research Institute, Xining, China.
Tianyi WuNational Key Laboratory of High Altitude Medicine, Qinghai High Altitude Medical Research Institute, Xining, China.
Shangang JiaCollege of Grassland Science and Technology, China Agricultural University, Beijing, China.
Yanming ZhangKey Laboratory of Adaptation and Evolution of Plateau Biota, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, China.
Chinese Academy of Sciences · CNChina Agricultural University · CNXinjiang Institute of Ecology and Geography · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronary heart disease (CHD) is closely related to gut microbiota, which may be significantly affected by ethnicity and the environment. Knowledge regarding the gut microbiome of Tibetan CHD patients living in the Qinghai-Tibet Plateau is very limited. In this study, we characterized the physiological parameters and gut microbiota from 23 healthy Tibetans (HT), 18 CHD patients, and 12 patients with non-stenosis coronary heart disease (NCHD). We analyzed the alterations of the gut microbiome in CHD patients and investigated the relationship between these alterations and the pathological indicators. We found no changes in trimethylamine N-oxide, however, a significant increase in lipopolysaccharides and white blood cells, and a decrease in high-density lipoprotein were observed in the blood of CHD patients, compared to that in the HT group. The gut microbiota of the NCHD group had a significantly higher Shannon index than that of the HT group. Adonis analysis showed that both microbial compositions and functions of the three groups were significantly separated. The

Indexed as

Coronary DiseaseGastrointestinal MicrobiomeFecesHumansLipopolysaccharidesRisk FactorsTibetLipopolysaccharides16S rDNAcoronary heart disease (CHD)gut microbiomelipopolysaccharide (LPS)metagenomeTibetan

Identifiers

PMID32793515
PMCPMC7390946
OpenAlexW3043942360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.