Evidence map›Paper›PMID 32793512›Full record

ArticleFrontiers in cellular and infection microbiology2020

Human Cytomegalovirus Long Non-coding RNA1.2 Suppresses Extracellular Release of the Pro-inflammatory Cytokine IL-6 by Blocking NF-κB Activation.

Betty Lau, Karen Kerr, Quan Gu, Katie Nightingale, Robin Antrobus, Nicolás M Suárez, Richard J Stanton, Eddie C Y Wang, Michael P Weekes, Andrew J Davison

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
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  3. Shaping the host cell environment with viral noncoding RNAs.Seminars in cell & developmental biology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Betty LauMRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
Karen KerrMRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
Quan GuMRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
Katie NightingaleCambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Robin AntrobusCambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Nicolás M SuárezMRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
Richard J StantonDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Eddie C Y WangDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Michael P WeekesCambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Andrew J DavisonMRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
MRC University of Glasgow Centre for Virus Research · GBUniversity of Cambridge · GBCardiff University · GB

Funding

HCRW_ HS-14-11Medical Research Council MC_UU_12014/3Medical Research Council MR/L008734/1Medical Research Council MR/P001602/1Medical Research Council MR/S00971X/1Medical Research Council MR/S0097X/1Wellcome TrustWellcome Trust 108070/Z/15/Z
6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) are transcripts of >200 nucleotides that are not translated into functional proteins. Cellular lncRNAs have been shown to act as regulators by interacting with target nucleic acids or proteins and modulating their activities. We investigated the role of RNA1.2, which is one of four major lncRNAs expressed by human cytomegalovirus (HCMV), by comparing the properties of parental virus

Indexed as

CytomegalovirusInterleukin-6NF-kappa BCells, CulturedCytokinesFibroblastsHumansRNA, Long NoncodingRNA, ViralCytokinesInterleukin-6NF-kappa BRNA, Long NoncodingRNA, Viralgene regulationhuman cytomegalovirusIL-6lncRNANF-κBTPRG1Ltranscriptomics

Identifiers

PMID32793512
PMCPMC7387431
OpenAlexW3044064420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.