ArticleNPJ vaccines2020
Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19.
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Article in NPJ vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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93citing papers in PubMed
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Who cites it
93 citing papers in PubMed, 146 citations in OpenAlex.
- Evaluation of the contribution of the minor envelope complex glycoprotein 3 ectodomain to the porcine reproductive and respiratory syndrome virus 1 neutralizing antibody response.The Journal of general virology · 2026Article
- Vaccinology in the twenty-first century revisited.NPJ vaccines · 2026Article
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- Heterologous mucosal vaccine boosting enhances mucosal and systemic immunity by distinct mechanisms.The Journal of experimental medicine · 2026Article
- Phenotypic and functional changes to porcine monocyte-derived macrophages triggered by IL-1β and its receptor antagonist IL-1Ra.Frontiers in immunology · 2026Article
- Intelligence Disclosure on Deploying SpyTag/SpyCatcher for Nanoparticle Assembly.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Nipah virus vaccines evaluated in pigs as a 'One Health' approach to protect public health.NPJ vaccines · 2025Article
- Biocompatibility of Water-Dispersible Pristine Graphene and Graphene Oxide Using a Close-to-Human Animal Model: A Pilot Study on Swine.Advanced healthcare materials · 2025Article
- Differential efficacy of first licensed western vaccines protecting without immunopathogenesis Wuhan-1-challenged hamsters from severe COVID-19.NPJ vaccines · 2025Article
- Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease.Nature communications · 2025Article
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- A pseudotyped adenovirus serotype 5 vector with serotype 49 fiber knob is an effective vector for vaccine and gene therapy applications.Molecular therapy. Methods & clinical development · 2024Article
- Vaccine delivery systems and administration routes: Advanced biotechnological techniques to improve the immunization efficacy.Vaccine: X · 2024Review
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- mRNA and Adenoviral Vector Vaccine Platforms Utilized in COVID-19 Vaccines: Technologies, Ecosystem, and Future Directions.Vaccines · 2023Review
- Viral vectored vaccines: design, development, preventive and therapeutic applications in human diseases.Signal transduction and targeted therapy · 2023Review
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- Bibliometric Analysis of Global Scientific Production on COVID-19 and Vaccines.International journal of environmental research and public health · 2023Article
- Heterogeneity of Phenotypic and Functional Changes to Porcine Monocyte-Derived Macrophages Triggered by Diverse Polarizing Factors In Vitro.International journal of molecular sciences · 2023Article
33 more citing papers are in PubMed but not listed here.
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Authors and funding
42 authors at 4 institutions in 1 country.
Simon P GrahamThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.ORCID 0000-0003-4852-405X
Rebecca K McLean *The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.ORCID 0000-0002-4688-3019
Alexandra J Spencer *The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ UK.
Sandra Belij-RammerstorferThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ UK.
Daniel WrightThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ UK.ORCID 0000-0002-8114-1838
Marta UlaszewskaThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ UK.
Jane C EdwardsThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
Jack W P HayesThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.ORCID 0000-0003-3984-4764
Veronica MartiniThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
Nazia ThakurThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.ORCID 0000-0002-4450-5911
Carina ConceicaoThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
Isabelle DietrichThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
Holly SheltonThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.ORCID 0000-0002-5776-0735
Ryan WatersThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.ORCID 0000-0002-4174-1150
Anna LudiThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.ORCID 0000-0001-8554-5234
Ginette WilsdenThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
Clare BrowningThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
Dagmara BialyThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
Sushant BhatThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.ORCID 0000-0003-1869-6176
Phoebe Stevenson-LeggettThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
Philippa HollinghurstThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.ORCID 0000-0003-0768-2879
Ciaran GilbrideThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ UK.
David PulidoThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ UK.ORCID 0000-0003-3422-0434
Katy MoffatThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
Hannah SharpeThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ UK.ORCID 0000-0002-1194-2429
Elizabeth AllenThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ UK.ORCID 0000-0002-6406-4834
Valerie MiouletThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
Chris ChiuThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
Joseph NewmanThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
Amin S AsforThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
Alison BurmanThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
Sylvia CrossleyThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
Jiandong HuoProtein Production UK, Research Complex at Harwell, and Rosalind Franklin Institute Rutherford Appleton Laboratory Harwell Oxford, Didcot, OX11 0FA UK.
Raymond J OwensProtein Production UK, Research Complex at Harwell, and Rosalind Franklin Institute Rutherford Appleton Laboratory Harwell Oxford, Didcot, OX11 0FA UK.ORCID 0000-0002-3705-2993
Miles CarrollPublic Health England, Manor Farm Road, Salisbury, SP4 0JG UK.
John A HammondThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.ORCID 0000-0002-2213-3248
Elma TchilianThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.ORCID 0000-0002-4869-5118
Dalan BaileyThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
Bryan CharlestonThe Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
Sarah C GilbertThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ UK.ORCID 0000-0002-6823-9750
Tobias J Tuthill *The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.ORCID 0000-0002-6582-388X
Teresa Lambe *The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ UK.ORCID 0000-0001-7711-897X
The Pirbright Institute · GBUniversity of Oxford · GBRutherford Appleton Laboratory · GBPublic Health England · GB
Funding
Biotechnology and Biological Sciences Research Council BBS/E/I/00007031Biotechnology and Biological Sciences Research Council BBS/E/I/00007034Biotechnology and Biological Sciences Research Council BBS/E/I/00007037Biotechnology and Biological Sciences Research Council BBS/E/I/00007038Biotechnology and Biological Sciences Research Council BBS/E/I/00007039NIAID NIH HHS HHSN272201400008C
Abstract
Clinical development of the COVID-19 vaccine candidate ChAdOx1 nCoV-19, a replication-deficient simian adenoviral vector expressing the full-length SARS-CoV-2 spike (S) protein was initiated in April 2020 following non-human primate studies using a single immunisation. Here, we compared the immunogenicity of one or two doses of ChAdOx1 nCoV-19 in both mice and pigs. Whilst a single dose induced antigen-specific antibody and T cells responses, a booster immunisation enhanced antibody responses, particularly in pigs, with a significant increase in SARS-CoV-2 neutralising titres.
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