ArticleRegenerative biomaterials2020
Characterization and biological evaluation of a novel silver nanoparticle-loaded collagen-chitosan dressing.
Article in Regenerative biomaterials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Integrated bioinformatic identification and translational validation of key biomarkers and therapeutic candidates for preeclampsia-related acute kidney injury.Archives of gynecology and obstetrics · 2026Article
- Delivery of TCM Monomers Using Blood Cell Membrane Coated Biomimetic Nanoparticles to Target CVD.International journal of nanomedicine · 2026Review
- A novel collagen hydrogel loaded with primary brown sugar for accelerating burn wound healing by a synergistic mechanism.Regenerative biomaterials · 2026Article
- An Anti-Inflammatory and Pro-Angiogenic Porous Aloe Polysaccharide-Collagen Dressing Accelerates Wound Healing.ACS applied bio materials · 2025Article
- Noscapine-loaded collagen-based silver nanoparticles: a potent nano-therapeutic approach for cancer treatment.RSC advances · 2025Article
- Progress in Research on Animal Collagen Peptides: Preparation, Bioactivity, and Application.Molecules (Basel, Switzerland) · 2025Review
- Chitosan hydrogels loaded with CuScientific reports · 2025Article
- Assessing the Effects of Surface-Stabilized Zero-Valent Iron Nanoparticles on Diverse Bacteria Species Using Complementary Statistical Models.Journal of functional biomaterials · 2025Article
- Review
- Synthesis and Characterization of Multifunctional Chitosan-Silver Nanoparticles: An In-Vitro Approach for Biomedical Applications.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Article
- Exploring an Innovative Approach: Integrating Negative-Pressure Wound Therapy with Silver Nanoparticle Dressings in Skin Graft Procedures.Journal of personalized medicine · 2024Article
- Collagen-Based Nanoparticles as Drug Delivery System in Wound Healing Applications.International journal of nanomedicine · 2024Review
- Tailored biomedical materials for wound healing.Burns & trauma · 2023Review
- Nanoparticle-Containing Wound Dressing: Antimicrobial and Healing Effects.Gels (Basel, Switzerland) · 2022Review
- An injectable metal nanoparticle containing cellulose derivative-based hydrogels: Evaluation of antibacterial and in vitro-vivo wound healing activity in children with burn injuries.International wound journal · 2022Article
- Recent advances in regenerative biomaterials.Regenerative biomaterials · 2022Review
- A sandwich structure composite wound dressing with firmly anchored silver nanoparticles for severe burn wound healing in a porcine model.Regenerative biomaterials · 2021Article
- The Kinetics of Chitosan Degradation in Organic Acid Solutions.Marine drugs · 2021Article
- Antioxidant biocompatible composite collagen dressing for diabetic wound healing in rat model.Regenerative biomaterials · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effective coverage and protection is a priority in wound treatment. Collagen and chitosan have been widely used for wound dressings due to their excellent biological activity and biocompatibility. Silver nanoparticles (AgNPs) have a powerful antibacterial effect. In this study, a macromolecular and small-molecular collagen mixed solution, a macromolecular and small-molecular chitosan mixed solution were prepared, and a silver nanoparticle-loaded collagen-chitosan dressing (AgNP-CCD) has been proposed. First, the effects of a collagen-chitosan mixed solution on the proliferation of human umbilical vein endothelial cells and the secretion of cytokines were evaluated. Then, the characteristics and antibacterial effects of the AgNP-CCD were tested, and the effects on wound healing and the influence of wound cytokine expression were investigated via a deep second-degree burn wound model. The results showed that at the proper proportion and concentration, the collagen-chitosan mixed solution effectively promoted cell proliferation and regulated the levels of growth factors (vascular endothelial growth factor [VEGF], epidermal growth factor [EGF], platelet-derived growth factor [PDGF], transforming growth factor [TGF-β1], basic fibroblastic growth factor [bFGF]) and inflammatory factors (TNF-α, IL-1β, IL-6, IL-8). Moreover, AgNP solutions at lower concentrations exerted limited inhibitory effects on cell proliferation and had no effect on cytokine secretion. The AgNP-CCD demonstrated satisfactory morphological and physical properties as well as efficient antibacterial activities. An
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.