Evidence map›Paper›PMID 32793376›Full record

ArticleFertility research and practice2020

Inability to obtain sperm for fresh IVF cycles: analysis and incidence of outcomes using a database from the United States.

Alexandra Joice Berger, Valary Raup, Ramy Abou Ghayda, Andrea Lanes, Martin Kathrins

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fertility research and practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07074015 (IntelliWell), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07074015 narecruitingnot on this mapstarted 2026, after this paper: background citation

IntelliWell: An AI-Assisted Microwell Platform for Label-Free Localization of Ultra-Rare Sperm in Non-Obstructive Azoospermia Micro-TESE Specimens

TypeinterventionalSponsorBrigham and Women's HospitalRan2026 to 2027Enrolled20ConditionsInfertility, AzoospermiaArmsUse of IntelliWell to identify and localize sperm for ICSI
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Fresh versus frozen micro-TESE sperm and outcomes.Asian journal of andrology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Alexandra Joice BergerDivision of Urology, Brigham and Women's Hospital and Harvard Medical School, 45 Francis St ASB-II, Boston, MA 02115 USA.ORCID 0000-0002-2522-9392
Valary RaupDivision of Urology, Brigham and Women's Hospital and Harvard Medical School, 45 Francis St ASB-II, Boston, MA 02115 USA.
Ramy Abou GhaydaDivision of Urology, Brigham and Women's Hospital and Harvard Medical School, 45 Francis St ASB-II, Boston, MA 02115 USA.
Andrea LanesDepartment of Obstetrics and Gynecology, Center for Infertility and Reproductive Surgery, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115 USA.
Martin KathrinsDivision of Urology, Brigham and Women's Hospital and Harvard Medical School, 45 Francis St ASB-II, Boston, MA 02115 USA.
Brigham and Women's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAzoospermia is present in 10% of men presenting with infertility and surgical sperm retrieval rates for men with azoospermia due to spermatogenic dysfunction remain low. We investigated the incidence of failed fresh IVF cycles due to inability to obtain sperm and describe predictors for subsequent IVF.

methodsA national IVF database was used to identify fresh IVF cycles in which there was failure to obtain sperm. Patient linkage was utilized to determine outcomes of subsequent IVF.

results243,291 fresh IVF cycles were identified; 719 (0.3%) listed "inability to obtain sperm" as reason for embryo non-transfer. Male infertility was a factor in 537 (75%) and ejaculation was the most common anticipated sperm source (414, 57%). 713 (99.2%) cycles resulted in retrieved oocytes, but only 627 (87.2%) cryopreserved oocytes. 265 (37%) of couples underwent subsequent IVF. On multivariable analysis, lack of initial oocyte cryopreservation (OR 0.34,

conclusionsFailure to obtain sperm during fresh IVF is rare, but most affected couples will not pursue further cycles of IVF after their initial failed attempt.

Identifiers

PMID32793376
PMCPMC7418387
OpenAlexW3048428254

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.