Evidence map›Paper›PMID 32792940›Full record

ArticleFrontiers in aging neuroscience2020

The Validation of Multifactor Model of Plasma Aβ

Fubin Jiao, Fang Yi, Yuanyuan Wang, Shouzi Zhang, Yanjun Guo, Wenjin Du, Ya Gao, Jingjing Ren, Haifeng Zhang, Lixin Liu and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Simple Plasma Test Based on a MoSeChemical & biomedical imaging · 2023
    Article
  12. Examining the Effects of Formal Education Level on the Montreal Cognitive Assessment.Journal of the American Board of Family Medicine : JABFM · 2022
    Article
  13. Article
  14. Article
  15. Review
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  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Fubin JiaoMedical School of Chinese People's Liberation Army, Beijing, China.
Fang YiDepartment of Neurology, The 2nd Medical Center, National Clinical Research Center for Geriatric Disease, Chinese People's Liberation Army General Hospital, Beijing, China.
Yuanyuan WangDepartment of Neurology, The 2nd Medical Center, National Clinical Research Center for Geriatric Disease, Chinese People's Liberation Army General Hospital, Beijing, China.
Shouzi ZhangThe Psycho Department of Beijing Geriatric Hospital, Beijing, China.
Yanjun GuoDepartment of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Wenjin DuDepartment of Neurology, Air Force Medical Center, Chinese People's Liberation Army, Beijing, China.
Ya GaoDepartment of Geriatrics, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Jingjing RenNational Engineering Research Center for Protein Drugs, Beijing, China.
Haifeng ZhangHealth Service Department of the Guard Bureau of the Joint Staff Department, Joint Staff of the Central Military Commission of Chinese PLA, Beijing, China.
Lixin LiuThe Psycho Department of Beijing Geriatric Hospital, Beijing, China.
Haifeng SongNational Engineering Research Center for Protein Drugs, Beijing, China.
Luning WangMedical School of Chinese People's Liberation Army, Beijing, China.
Chinese People's Liberation Army · CNBeijing Geriatric Hospital · CNBeijing Friendship Hospital · CNCentral Military Commission · CNChinese People’s Liberation Army 263 hospital · CNHebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer disease (AD) has an insidious onset and heterogeneous clinical symptoms. The well-accepted biomarkers for clinical diagnosis of AD include β-amyloid (Aβ) deposition and pathologic tau level within cerebral spinal fluid (CSF) and imaging AD pathology such as positive emission tomography (PET) imaging of the amyloid-binding agent Pittsburgh compound B (PET-PiB). However, the high expense and invasive nature of these methods highly limit their wide usage in clinic practice. Therefore, it is imperious to develop less expensive and invasive methods, and plasma biomarkers are the premium targets. In the current study, we utilized a single-blind comparison method; all the probable AD cases met the core clinical National Institute on Aging and Alzheimer's Association (NIA-AA) criteria and validated by PET-PiB. We used ultrasensitive immunomagnetic reduction (IMR) assays to measure plasma Aβ

Indexed as

Alzheimer diseaseMontreal Cognitive Assessmenttauultrasensitive immunomagnetic reductionβ-amyloid

Identifiers

PMID32792940
PMCPMC7385244
OpenAlexW3044530984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.