ArticleFrontiers in systems neuroscience2020
Altered Pallidocortical Low-Beta Oscillations During Self-Initiated Movements in Parkinson Disease.
Article in Frontiers in systems neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Using Magnetoencephalography to Advance the Science of Parkinson Disease: A Systematic Review.Brain and behavior · 2025Pooled it
- Cortical-to-pallidal beta cascade underlies network pathophysiology in Parkinson's disease.Cell reports. Medicine · 2026Article
- Aberrant Beta-Band Network Alteration Preceding Freezing of Gait in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Complementary cortical and striatal encoding of locomotor preparation and performance.iScience · 2025Article
- Beta burst characteristics predict instantaneous hand movements in Parkinson's disease.Neurobiology of disease · 2025Article
- Theta and beta power in the subthalamic nucleus responds to conflict across subregions and hemispheres.Brain communications · 2025Article
- Prefrontal-subthalamic theta signaling mediates delayed responses during conflict processing.Progress in neurobiology · 2024Article
- Irregularity of instantaneous gamma frequency in the motor control network characterize visuomotor and proprioceptive information processing.Journal of neural engineering · 2024Article
- Apathy scores in Parkinson's disease relate to EEG components in an incentivized motor task.Brain communications · 2024Article
- The neuromechanical of Beta-band corticomuscular coupling within the human motor system.Frontiers in neuroscience · 2024Review
- Deep brain stimulation rectifies the noisy cortex and irresponsive subthalamus to improve parkinsonian locomotor activities.NPJ Parkinson's disease · 2022Article
- Novel approaches for quantifying beta synchrony in Parkinson's disease.Experimental brain research · 2022Review
- Dorsal visual stream is preferentially engaged during externally guided action selection in Parkinson Disease.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022Article
- Large-scale frontoparietal theta, alpha, and beta phase synchronization: A set of EEG differential characteristics for freezing of gait in Parkinson's disease?Frontiers in aging neuroscience · 2022Article
- Attenuation of neural responses in subthalamic nucleus during internally guided voluntary movements in Parkinson's disease.Frontiers in human neuroscience · 2022Article
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7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParkinson disease (PD) patients have difficulty with self-initiated (SI) movements, presumably related to basal ganglia thalamocortical (BGTC) circuit dysfunction, while showing less impairment with externally cued (EC) movements.
objectivesWe investigate the role of BGTC in movement initiation and the neural underpinning of impaired SI compared to EC movements in PD using multifocal intracranial recordings and correlating signals with symptom severity.
methodsWe compared time-resolved neural activities within and between globus pallidus internus (GPi) and motor cortex during between SI and EC movements recorded invasively in 13 PD patients undergoing deep brain stimulation implantation. We compared cortical (but not subcortical) dynamics with those recorded in 10 essential tremor (ET) patients, who do not have impairments in movement initiation.
resultsSI movements in PD are associated with greater low-beta (13-20 Hz) power suppression during pre-movement period in GPi and motor cortex compared to EC movements in PD and compared to SI movements in ET (motor cortex only). SI movements in PD are uniquely associated with significant low-beta pallidocortical coherence suppression during movement execution that correlates with bradykinesia severity. In ET, motor cortex neural dynamics during EC movements do not significantly differ from that observed in PD and do not significantly differ between SI and EC movements.
conclusionThese findings implicate low beta BGTC oscillations in impaired SI movements in PD. These results provide a physiological basis for the strategy of using EC movements in PD, circumventing diseased neural circuits associated with SI movements and instead engaging circuits that function similarly to those without PD.
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