ArticleFrontiers in neuroscience2020
Development of a Fully Implantable Stimulator for Deep Brain Stimulation in Mice.
Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Molecular glucose imaging reveals functional brain reconfiguration by subthalamic deep brain stimulation in Parkinsonian rats.Translational neurodegeneration · 2025Article
- A wearable deep brain stimulation system for behavioral studies in rodents.Frontiers in neuroscience · 2025Article
- A framework for translational therapy development in deep brain stimulation.NPJ Parkinson's disease · 2024Review
- Standardized wireless deep brain stimulation system for mice.NPJ Parkinson's disease · 2024Article
- Hypothalamic deep brain stimulation as a strategy to manage anxiety disorders.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Directions of Deep Brain Stimulation for Epilepsy and Parkinson's Disease.Frontiers in neuroscience · 2021Review
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDeep brain stimulation is an established method for the treatment of neurological and psychiatric disorders. To elicit the underlying mechanisms and explore new stimulation targets, rodent models are necessary. Cable bound external stimulation or portable devices limit movement of the animals and influence behavioral experiments. Therefore, implantable, individually programmed devices are required. EXPERIMENTAL PROCEDURE: The stimulator consists of an 8bit-microcontroller mounted on a square electrical board (10 × 10 mm). External control is enabled by a magnetic reed contact, as running control serves a white LED, running modes are displayed by flash codes. Stimulation parameters could be programmed in the range of pulse width: 60-500 μs, amplitude: up to 300 μA and frequency: 10-500 Hz. Power is supplied by two standard batteries. The device was implanted in 8-10 weeks old BALBc-mice. Functionality was examined by electrical stimulation of nucleus accumbens area with standard parameters for mice and determination of c-fos levels
resultsThe implanted microstimulators were well-tolerated by the mice, without impairment of free movement. Coating, external control, and monitoring of function with LED flash code proved to be fully adequate. Stimulation with standard stimulating parameters of nucleus accumbens elicited strong c-fos elevation on simulation site.
conclusionWe present a fully implantable stimulator for freely moving mice that meets the urgent need for further research on the effects of deep brain stimulation in rodent models. It offers the possibility to conduct behavioral experiments for up to 30 days of stimulation.
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