Evidence map›Paper›PMID 32792874›Full record

ArticlePostepy dermatologii i alergologii2020

Biochemical and histopathologic assessment of effects of acitretin on epiphyseal growth plate in rats.

Sevda Onder, Serap Gunes Bilgili, Gulay Bulut, Huseyin Tugrul Celik, Serpil Oguztuzun, Hacı Onder, Omer Calka, Ayse Serap Karadag

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Postepy dermatologii i alergologii, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Sevda OnderDepartment of Dermatology, Faculty of Medicine, Ordu University, Ordu, Turkey.
Serap Gunes BilgiliDepartment of Dermatology, Faculty of Medicine, Yuzuncu Yıl University, Van, Turkey.
Gulay BulutDepartment of Pathology, Faculty of Medicine, Yuzuncu Yıl University, Van, Turkey.
Huseyin Tugrul CelikDepartment of Biochemistry, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey.
Serpil OguztuzunDepartment of Biology, Faculty of Arts and Sciences, Kırıkkale University, Kırıkkale, Turkey.
Hacı OnderDepartment of Orthopaedics and Traumatology, Ordu University Training and Research Hospital, Ordu, Turkey.
Omer CalkaDepartment of Dermatology, Faculty of Medicine, Yuzuncu Yıl University, Van, Turkey.
Ayse Serap KaradagDepartment of Dermatology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.
Van Yüzüncü Yıl Üniversitesi · TROrdu University · TRIstanbul Medeniyet University · TRKırıkkale University · TRTurgut Özal University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAcitretin is a commonly used retinoid in dermatology. Although there are generally known side effects, the effects on the epiphyseal plaque and bone metabolism are not clear in the literature.

aimTo histopathologically investigate the effects on the epiphyseal plate and assess variations in bone metabolism caused by acitretin. MATERIAL AND

methodsThree groups were formed with 10 rats in each group. The 1

resultsStaining with haematoxylin-eosin found reductions in the epiphyseal plate in the 1

conclusionsOur data show that though acitretin caused degeneration of the epiphyseal plate, it did not cause clear thinning and we identified no significant variations in bone metabolism markers.

Indexed as

acitretinbone metabolismepiphyseal platerat

Identifiers

PMID32792874
PMCPMC7394155
OpenAlexW3045024753

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.