ReviewMucosal immunology2020
Microbial modulation of intestinal T helper cell responses and implications for disease and therapy.
Review in Mucosal immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Strain-level antigen variation facilitates immune evasion in Bacteroides thetaiotaomicron.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Beyond Organ Boundaries: Molecular Mechanisms of Hepatic Encephalopathy and Parkinson's Disease from the Perspective of the Gut-Liver-Brain Axis.Research (Washington, D.C.) · 2026Review
- Guardians within: Cross-talk between the gut microbiome and host immune system.World journal of gastrointestinal pathophysiology · 2025Review
- Targeting gut microbiota for immunotherapy of diseases.Archives of toxicology · 2024Review
- Thymic Stromal Lymphopoietin and Tezepelumab in Airway Diseases: From Physiological Role to Target Therapy.International journal of molecular sciences · 2024Review
- Bowel function and inflammation: Is motility the other side of the coin?World journal of gastroenterology · 2024Article
- The improvement of immunity and activation of TLR2/NF-κB signaling pathway by Romboutsia ilealis in broilers.Journal of animal science · 2024Article
- Effects of the commensal microbiota on spleen and mesenteric lymph node immune function: investigation in a germ-free piglet model.Frontiers in microbiology · 2024Article
- Article
- Microbiome influencers of checkpoint blockade-associated toxicity.The Journal of experimental medicine · 2023Article
- Contributions of the microbiota to the systemic inflammatory response.Microbiota and host · 2023Article
- Microbial Components and Effector Molecules in T Helper Cell Differentiation and Function.Immune network · 2023Review
- Intestinal colonization regulates systemic anti-commensal immune sensitivity and hyperreactivity.Frontiers in immunology · 2023Article
- Context-Dependent Regulation of Type17 Immunity by Microbiota at the Intestinal Barrier.Immune network · 2022Review
- A conserved Bacteroidetes antigen induces anti-inflammatory intestinal T lymphocytes.Science (New York, N.Y.) · 2022Article
- From germ-free to wild: modulating microbiome complexity to understand mucosal immunology.Mucosal immunology · 2022Review
- Single-cell atlas of the aging mouse colon.iScience · 2022Article
- The impact of the gut microbiota on T cell ontogeny in the thymus.Cellular and molecular life sciences : CMLS · 2022Review
- Mechanistic Insights Into Gut Microbiome Dysbiosis-Mediated Neuroimmune Dysregulation and Protein Misfolding and Clearance in the Pathogenesis of Chronic Neurodegenerative Disorders.Frontiers in neuroscience · 2022Review
- Effects of gut microbiota on immune responses and immunotherapy in colorectal cancer.Frontiers in immunology · 2022Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Induction of intestinal T helper cell subsets by commensal members of the intestinal microbiota is an important component of the many immune adaptations required to establish host-microbial homeostasis. Importantly, altered intestinal T helper cell profiles can have pathological consequences that are not limited to intestinal sites. Therefore, microbial-mediated modulation of the intestinal T helper cell profile could have strong therapeutic potentials. However, in order to develop microbial therapies that specifically induce the desired alterations in the intestinal T helper cell compartment one has to first gain a detailed understanding of how microbial composition and the metabolites derived or induced by the microbiota impact on intestinal T helper cell responses. Here we summarize the milestone findings in the field of microbiota-intestinal T helper cell crosstalk with a focus on the role of specific commensal bacteria and their metabolites. We discuss mechanistic mouse studies and are linking these to human studies where possible. Moreover, we highlight recent advances in the field of microbial CD4 T cell epitope mimicry in autoimmune diseases and the role of microbially-induced CD4 T cells in cancer immune checkpoint blockade therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.