ArticleJournal of perinatology : official journal of the California Perinatal Association2021
Characteristics and outcomes of preterm neonates according to number of doses of surfactant received.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Elective high frequency oscillatory ventilation versus conventional mechanical ventilation on the chronic lung disease or death in preterm infants administered surfactant: a systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2025Pooled it
- Predictive Ability of Lung Ultrasound Score for Response to Surfactant Replacement Therapy in Preterm Neonates with Respiratory Distress Syndrome (PLUS-RDS Study).Indian pediatrics · 2026Article
- Comparison of LISA and INSURE techniques for surfactant administration: a multicentre retrospective study.European journal of pediatrics · 2026Article
- Surfactant retreatment in very preterm infants with respiratory distress syndrome: an observational cohort study.Translational pediatrics · 2026Article
- Effectiveness of surfactant treatment and retreatment in moderately preterm infants.Translational pediatrics · 2025Article
- Clinical predictors for surfactant retreatment in preterm infants with respiratory distress syndrome: the results of a pooled analysis.Italian journal of pediatrics · 2025Article
- Risk factors for the time to development of retinopathy of prematurity in premature infants in Iran: a machine learning approach.BMC ophthalmology · 2024Article
- Construction of a nomogram model to predict the risk of retinopathy of prematurity reactivate after intravitreal anti-vascular endothelial growth factor therapy: a retrospective study.Frontiers in pediatrics · 2024Article
- Early-onset neonatal sepsis as a risk factor for peri-intraventricular hemorrhage in premature infants.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2024Article
- Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Observational
- Poractant alfa versus bovine lipid extract surfactant: prospective comparative effectiveness study.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Safety and efficacy of a novel double-lumen tracheal tube in neonates with RDS: A prospective cohort study.Frontiers in pediatrics · 2022Article
- Article
- Outcome of Very Premature Newborn Receiving an Early Second Dose of Surfactant for Persistent Respiratory Distress Syndrome.Frontiers in pediatrics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 7 institutions in 1 country.
Funding
Abstract
objectivesTo identify characteristics and outcomes of infants who received multiple doses of surfactant vs those who received one dose or none. STUDY
designIn this retrospective study, we included neonates of 22-28 weeks' gestation admitted to NICUs in the Canadian Neonatal Network. Patients were divided into three groups: no surfactant, single dose, and multiple doses. The primary outcome was a composite of mortality or any of the major morbidities, including severe neurological injury, bronchopulmonary dysplasia, or ≥stage 3 retinopathy of prematurity.
resultsOf 8024 eligible neonates, 2461 (31%) did not receive surfactant, 3545 (44%) received one dose, and 2018 (25%) received >1 dose. Receiving one or more doses of surfactant was associated with significantly higher adjusted odds of mortality or major morbidities in a dose-dependent manner.
conclusionsReceiving one or more doses of surfactant was associated with adverse neonatal outcomes. Receipt of more than one dose may reflect underlying severe lung immaturity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.