ArticleJournal of perinatology : official journal of the California Perinatal Association2021
Delivery-based criteria for empiric antibiotic administration among preterm infants.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Gut microbiome in preterm infants with different weight gain outcomes.Gut microbiology · 2026Article
- Long-term sustainability and safety of a delivery-based early-onset sepsis evaluation strategy for very low birth weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Association between initial empirical antibiotic therapy and necrotizing enterocolitis in very preterm infants at different risk for early-onset sepsis: a multicenter cohort study.BMC pregnancy and childbirth · 2026Observational
- Antibiotic use among extremely low birth-weight infants from 2009 to 2021: a retrospective observational study.Archives of disease in childhood. Fetal and neonatal edition · 2025Observational
- Sustaining the Continued Effectiveness of an Antimicrobial Stewardship Program in Preterm Infants.Tropical medicine and infectious disease · 2024Article
- Trends in prostate cancer mortality in the United States of America, by state and race, from 1999 to 2019: estimates from the centers for disease control WONDER database.Prostate cancer and prostatic diseases · 2023Article
- Early antibiotic exposure in very-low birth weight infants and infection risk at 3-7 days after birth.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Association of delivery risk phenotype with early-onset sepsis in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Diagnostic Performance and Patient Outcomes With C-Reactive Protein Use in Early-Onset Sepsis Evaluations.The Journal of pediatrics · 2023Article
- Influences of Initial Empiric Antibiotics with Ampicillin plus Cefotaxime on the Outcomes of Neonates with Respiratory Failure: A Propensity Score Matched Analysis.Antibiotics (Basel, Switzerland) · 2023Article
- Early antibiotics and risk for necrotizing enterocolitis in premature infants: A narrative review.Frontiers in pediatrics · 2023Review
- Article
- Practice Summary of Antimicrobial Therapy for Commonly Encountered Conditions in the Neonatal Intensive Care Unit: A Canadian Perspective.Frontiers in pediatrics · 2022Review
- Noninfectious influencers of early-onset sepsis biomarkers.Pediatric research · 2022Review
- Phenotyping preterm infants at birth to predict infection risk.Pediatric research · 2021Article
- Preterm infants at low risk for early-onset sepsis differ in early fecal microbiome assembly.Gut microbesArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveDetermine impact of using delivery criteria to initiate antibiotics among very low birth weight (VLBW) and extremely low birth weight (ELBW) infants. STUDY
designSingle site cohort study from 01/01/2009 to 01/31/2020. After 04/2017, infants delivered by Cesarean section, without labor or membrane rupture were categorized as low-risk for early-onset infection and managed without empiric antibiotics. We determined effect of this guideline by pre-post, and interrupted time-series analyses.
resultsAfter 04/2017, antibiotic initiation ≤3 days decreased among low-risk VLBW (62% vs. 13%, p < 0.001) and low-risk ELBW (88% vs. 21%, p < 0.001) infants. In time series analysis, guideline was associated with decreased initiation among low-risk ELBW infants. In contrast, low-risk VLBW infants demonstrated decreased antibiotic initiation throughout study period. Incidence of confirmed infection, death, or transfer ≤7 days age was unchanged.
conclusionDelivery criteria may be used to optimize early antibiotic initiation among preterm infants without short-term increase in adverse outcomes.
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Registered trials
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