Evidence map›Paper›PMID 32792549›Full record

ArticleScientific reports2020

Upregulation of circ_0000199 in circulating exosomes is associated with survival outcome in OSCC.

Yanwei Luo, Fengxia Liu, Jie Guo, Rong Gui

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Pooled it
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  3. Circular RNA as a Potential Biomarker for Melanoma: A Systematic Review.Frontiers in cell and developmental biology · 2021
    Pooled it
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  12. Emerging roles of exosomes in oral diseases progression.International journal of oral science · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yanwei LuoDepartment of Blood Transfusion, The Third Xiangya Hospital of Central South University, Tongzipo Road 138, Changsha, 410013, Hunan, China.
Fengxia LiuDepartment of Blood Transfusion, The Third Xiangya Hospital of Central South University, Tongzipo Road 138, Changsha, 410013, Hunan, China.
Jie GuoNational Institution of Drug Clinical Trial, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, 410008, Hunan, P.R. China. xiangyaguojie@hotmail.com.
Rong GuiDepartment of Blood Transfusion, The Third Xiangya Hospital of Central South University, Tongzipo Road 138, Changsha, 410013, Hunan, China. aguirong@163.com.
Central South University · CNXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies have found that circRNA in exosomes is associated with oral squamous cell carcinoma (OSCC) progression. In this study, we examined the expression of circ_0000199 in circulating exosomes from patients with OSCC and its role in the evaluation of relapse and prognosis. Real-time quantitative reverse transcription-polymerase chain reaction was performed to assess circ_0000199 expression in circulating exosomes from 108 patients with OSCC and 50 healthy people. Gain- and loss-functional experiments were performed to assess the role of circ_0000199 on cell proliferation and apoptosis in OSCC cells. Our results showed that the high level of circ_0000199 in circulating exosomes was significantly associated with betel quid chewing, tumor size, lymphatic metastasis, and TNM stage in patients with OSCC. In addition, the patients with high exosomal circ_0000199 had higher tumor recurrence rate and higher mortality rate than the patients with low exosomal circ_0000199. Overexpression of circ_0000199 promoted, while knockdown of circ_0000199 inhibited OSCC cell growth. Bioinformatics analysis predicted that circ_0000199 interacted with miR-145-5p and miR-29b-3p simultaneously, which were involved in multiple tumor-related signaling pathways. In conclusion, upregulation of circ_0000199 in circulating exosomes from patients with OSCC is positively associated with poor survival outcome. Circulating exosomal circ_0000199 can be used as a biomarker and potential therapeutic target for OSCC.

Indexed as

ApoptosisBiomarkers, TumorCase-Control StudiesCell LineCell Line, TumorCell ProliferationExosomesFemaleHumansMaleMicroRNAsMiddle AgedMouth NeoplasmsNeoplasm Recurrence, LocalPrognosisRNA, CircularBiomarkers, TumorMicroRNAsRNA, Circular

Identifiers

PMID32792549
PMCPMC7426867
OpenAlexW3048730962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.