ArticleNature communications2020
Single-trial cross-area neural population dynamics during long-term skill learning.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- Prioritized nonlinear modeling of shared dynamics across neural populations.Journal of neural engineering · 2026Article
- Inferring brain-wide interactions using data-constrained recurrent neural network models.Neuron · 2026Article
- Article
- A communication subspace relays context-dependent actions from human prefrontal to motor cortex.Nature neuroscience · 2026Article
- Conserved role of primary motor cortex in the control of prehension in mice and macaques.Cell reports · 2026Article
- Benchmarking criteria to determine latent linear dimensionality in neural data.Scientific reports · 2026Article
- Interactions across hemispheres in prefrontal cortex reflect global cognitive processing.Nature communications · 2026Article
- Circuit Organization of the Forelimb-Related M2-to-M1 Corticocortical Pathway in the Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Shared somatosensory-motor neural population dynamics track motor recovery after stroke.bioRxiv : the preprint server for biology · 2026Article
- Mouse sensorimotor cortex reflects complex kinematic details during reaching and grasping.eLife · 2026Article
- Circuit organization of the forelimb-related M2-to-M1 corticocortical pathway in the mouse.bioRxiv : the preprint server for biology · 2026Article
- Linking systemic metabolic state to long-term motor memory: Insights from respiratory exchange ratio and glucose manipulation.The Journal of physiology · 2026Article
- Subspace communication in the hippocampal-retrosplenial axis.bioRxiv : the preprint server for biology · 2026Article
- Forelimb Motor Learning and Memory Consolidation Drives Distinct Oligodendrocyte Plasticity to Regulate Task-related Neuronal Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Interactions between motor cortical forelimb regions and their influence on muscles reorganize across behaviors.Nature communications · 2025Article
- Selective coupling and decoupling coordinate distributed brain networks for precise action.bioRxiv : the preprint server for biology · 2025Article
- Accurate Identification of Communication Between Multiple Interacting Neural Populations.ArXiv · 2025Article
- Hippocampal-Prefrontal Communication Subspaces Align with Behavioral and Network Patterns in a Spatial Memory Task.eNeuro · 2025Article
- Effective cerebellar neuroprosthetic control after stroke.Cell reports · 2025Article
- Coordinated multi-level adaptations across neocortical areas during task learning.Nature communications · 2025Article
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4 authors.
Funding
Abstract
Mammalian cortex has both local and cross-area connections, suggesting vital roles for both local and cross-area neural population dynamics in cortically-dependent tasks, like movement learning. Prior studies of movement learning have focused on how single-area population dynamics change during short-term adaptation. It is unclear how cross-area dynamics contribute to movement learning, particularly long-term learning and skill acquisition. Using simultaneous recordings of rodent motor (M1) and premotor (M2) cortex and computational methods, we show how cross-area activity patterns evolve during reach-to-grasp learning in rats. The emergence of reach-related modulation in cross-area activity correlates with skill acquisition, and single-trial modulation in cross-area activity predicts reaction time and reach duration. Local M2 neural activity precedes local M1 activity, supporting top-down hierarchy between the regions. M2 inactivation preferentially affects cross-area dynamics and behavior, with minimal disruption of local M1 dynamics. Together, these results indicate that cross-area population dynamics are necessary for learned motor skills.
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